miR-143在脂肪细胞分化和脂类代谢中的作用  

The Role of miR-143 in the Adipocyte Differentiation and Lipid Metabolism

作　　者：李静[1] 黄英[1] 黄丽梅[2] 杨明华[1] 李琦华[1] 贾俊静[1] 赵素梅[1] 

机构地区：[1]云南农业大学云南省动物营养与饲料重点实验室,昆明650201 [2]云南农业大学党委宣传部,昆明650201

出　　处：《生物技术通报》2014年第9期34-38,共5页Biotechnology Bulletin

基　　金：国家高技术研究发展计划项目(2011AA100305);国家自然科学基金项目(30660132;31060331);云南省自然科学基金项目(2009CD056)

摘　　要：miR-143是内源性非编码的RNA,在细胞的分化、发育、增殖、脂肪代谢及疾病产生等许多生物学过程中具有重要作用。miR-143与脂类代谢密切相关,主要通过与靶基因的相互作用,影响脂肪的分化,甘油三酯的合成等。针对miR-143合成、预测的靶基因以及靶基因的调控机制方面进行综述,阐述miR-143在脂肪代谢中的作用,以便为相关疾病的诊断、治疗方面提供新思路。miR-143, discovered in recent years, is a non-coding RNA derived within a class, which plays an important role in many biological processes including cell differentiation, growth, proliferation, fat metabolism, disease and so on. miR-143 is closely related to the adipocyte differentiation and lipid metabolism, which could regulate the differentiation of adipocytes, synthetics of triglycerides primarily by the interaction with the target gene. The synthesis of miR-143, the interaction between miR-143 and the target genes to regulate adipocyte differentiation and lipid metabolism, in order to provide new ideas to the diagnosis and treatment for the obesity disease were reviewed.

关 键 词：微小RNA MIR-143 靶基因 脂类代谢 

分 类 号：Q254[生物学—细胞生物学] Q493.5