中医药治疗原发性肝癌用药规律文献分析  

Literature Research on TCM Medication Law of Primary Liver Cancer

作　　者：刘嘉辉[1] 邓金凤[1] 何洁茹[1] 吕东勇[2] 邝卫红[2] 

机构地区：[1]中山大学附属第一医院,广东省广州市中山二路58号510080 [2]广州中医药大学第一附属医院

出　　处：《中医杂志》2014年第18期1592-1595,共4页Journal of Traditional Chinese Medicine

摘　　要：目的基于文献分析中医药治疗原发性肝癌的用药规律。方法检索中国学术期刊全文数据库2004年1月至2013年12月中医药治疗原发性肝癌临床研究文献,建立治疗原发性肝癌的中药汤剂数据库,统计药物使用频次,并对药物进行功效、性、味、归经等描述性分析。结果共纳入文献167篇,涉及方剂172首,药物220味,共计2211药次。220味药物按功效可分为19类,按频率排前3位的依次为补虚药、清热药、活血化瘀药,药物累计频率达62.596%;使用频数>30的药物共20味,按频次排前5位的依次为茯苓、白术、黄芪、白花蛇舌草、甘草、柴胡;药性频数统计中,前3位依次为寒、平、温,寒性和微寒药物累计频率达40.74%;药味频数统计中,前3位依次为甘、苦、辛,苦、甘及微苦、微甘累计频率达62.94%。结论中医药治疗原发性肝癌将扶正和抗癌有机结合,在益气健脾基础上,常辨证施以清热解毒、活血化瘀和疏肝理气。Objective To analyze the traditional Chinese medicine（ TCM） medication law of primary liver cancer based on literature research.Methods The clinical research literature on TCM for primary liver cancer from January 2004 to December 2013 was searched in China National Knowledge Infrastructure（ CNKI）.A database of TCM decoctions for primary liver cancer was established.The frequency of medication was analyzed.The effect,nature,flavor and channel entry of herbs were descriptively analyzed.Methods Results A total of 167 articles were included.There were 172 prescriptions,220 herbs and 2211 herb frequency involved.The 220 herbs could be divided into 19 categories according to the effect.The top 3 were deficiency-supplementing herb,heat-clearing herb and blood-quickening stasis-transforming herb,with a total frequency of 62.60%.There were 20 herbs with a frequency greater than 30.The top 5 were Fuling（ 茯苓,Poria）,Baizhu（ 白术,Rhizoma Atractylodis Macrocephalae）,Huangqi（ 黄芪,Radix Astragali）,Baihuasheshecao（ 白花蛇舌草,Herba Hedyotis）,Gancao（ 甘草,Radix et Rhizoma Glycyrrhizae） and Chaihu（ 柴胡,Radix Bupleuri）.In the frequency of herb nature,the top 3 were cold,calm and warm.The total frequency of cold herbs and slightly cold herbs was 40.70%.In the frequency of herb flavor,the top3 were sweet,bitter and pungent.The total frequency of bitter,sweet,slightly bitter and slightly sweet herbs was62.94%.Conclusion On the basis of qi-boosting spleen-supplementing therapy,heat-clearing toxin-resolving therapy,blood-quickening stasis-transforming therapy and liver-coursing qi-rectifying therapy are often used in treating primary liver cancer.

关 键 词：原发性肝癌 中医药治疗 用药规律 文献分析 

分 类 号：R273[医药卫生—中西医结合]