多西紫杉醇修饰的人工晶体对眼组织相容性的影响  

Influence of Intraocular Lens Modified by Docetaxel to the Biocompatibility of Ocular Tissue

作　　者：余琦[1] 周炼红[2] 田明星[2] 

机构地区：[1]武汉大学基础医学院,湖北武汉430060 [2]武汉大学人民医院眼科

出　　处：《湖北科技学院学报（医学版）》2014年第4期280-282,共3页Journal of Hubei University of Science and Technology(Medical Sciences)

摘　　要：目的探讨多西紫杉醇修饰的人工晶体对眼组织相容性的影响,为人工晶体的新型生物材料提供依据。方法通过空气等离子技术,用多西紫杉醇对疏水性人工晶体表面进行修饰处理。16只日本大耳白兔随机分为对照组和实验组,每组8只。对照组:手术植入疏水性人工晶体;实验组:手术植入表面经多西紫杉醇修饰后疏水性人工晶体。比较人工晶体经多西紫杉醇处理后和处理前其表面亲水性的变化,两组均在手术后24h通过闪耀斑发生情况评估炎症感染程度,光镜下观察人工晶体周围组织炎症反应情况。结果通过对比多西紫杉醇处理前后的人工晶体亲水性改变,结果显示经过多西紫杉醇处理后晶体的亲水性明显增加,主要表现是接触角差异(78±6°VS 158±9°),与A组比较,B组的闪耀斑明显低于A组(230±10 VS 260±13);与A组比较,B组在术后24h植入的人工晶状体周围组织炎症细胞浸润计数结果明显低于A组(11±6 VS 103±22)。结论多西紫杉醇可通过等离子技术修饰人工晶体表面以增加其亲水性,进而增加了人工晶体和眼组织的组织相容性。Objective To study the influence of intraocular lens （IOL） modified by Docetaxel to the biocompatibility of ocular tissue in order to providing theoretical foundation for biological material. Methods The hydrophobicity IOL surface is pretreated by Docetaxel by the air plasma technique. 32 rabbits were randomly divided into control group （group A） and experimental group （group B）. Rabbits in Group A received conven- tional IOL through the general surgery, while rabbits in group B received the IOL pretreated by Docetaxel 24 hours after the operation, the inflammation was assessed by aqueous flare measurement in two groups. The inflammation of surrounding tissue was observed under light microscope. Results Compared the IOL pretreated by Docetaxel and the general IOL using the contact-angle goniometer, the result show that the former IOL contact angle decreased significantly. Compared with group A, aqueous flare in group B decreased significantly, and the infiltration of the inflammatory cells also decreaseed significantly. Conclusion Docetaxel could improve biocompatibility between the intraocular lens and the ocular tissue.

关 键 词：多西紫杉醇 人工晶体 疏水性 组织相容性 

分 类 号：R965[医药卫生—药理学]