血清可溶性粘附分子ICAM-1、VCAM-1与急性冠脉综合征及其预后的关系  

Relationship between Serum ICAM-1,VCAM-1Level and Acute Coronary Syndrome Prognosis

作　　者：杨群芳[1] 严伟玲[1] 

机构地区：[1]惠州市中医医院检验科,广东惠州516001

出　　处：《湖北科技学院学报（医学版）》2014年第4期285-288,共4页Journal of Hubei University of Science and Technology(Medical Sciences)

摘　　要：目的探讨血清中可溶性细胞间粘附分子(ICAM-1)和血管细胞间粘附分子(VCAM-1)与急性冠脉综合征(acute coronary syndrome,ACS)及其预后的关系。方法选择120例确诊的ACS患者与120例年龄、性别匹配的健康人群作为研究对象,使用问卷调查搜集研究对象一般资料,同时随访ACS患者不良心脑血管事件(MACCE)发生情况;使用全自动生化分析仪检测研究对象血清中总胆固醇、甘油三酯、血糖和超敏反应蛋白(hsCRP)水平,应用酶联免疫吸附法(ELISA)检测sVCAM-1和sICAM-1含量;分析VCAM-1和ICAM-1水平与ACS的关系。结果 ACS患者血清sVCAM-1和sICAM-1水平显著高于对照组(P<0.001),ACS患者中MACCE发生者血清sVCAM-1和sICAM-1水平也均显著高于非MACCE者(P<0.001);单因素及多因素Cox回归模型分析显示sVCAM-1是ACS患者发生MACCE的独立预测因素(单因素:RR=4.63,95%CI:1.87-11.52,P<0.001;多因素:RR=4.88,95%CI:1.39-12.67,P<0.001)。结论血清sVCAM-1水平可能与ACS发病有关,并且可以预测ACS患者的不良预后。Objective The purpose of this study was to investigate the relationship between serum ICAM-1, VCAM-1 level and acute coronary syndrome （ACS） prognosis. Methods A total of 120 hospitalized ACS patients and 120 age, sex matched healthy people with normal fasting serum were enrolled. The general information of object was collected by using the questionnaire survey and the occurrence of ACS patients with cardio cerebral vascular events （MACCE） was also followed up. Total cholesterol, triglycerides, glucose and hypersensitivity reaction protein （hsCRP） level in serum were detected by using full automatic biochemical analyzer. The levels of sICAM-1 and sVCAM-1 were quantified by enzyme-linked immunosorbent assay. The sta- tistical analysis included chi square test, t test and Cox regression model. Results The expression levels of sI- CAM-1 and sVCAM-1 in ACS patients were significant higher than that of control group （P 〈0. 001 ）. The ex- pression levels of sICAM-1 and sVCAM-1 in ACS patients with MACCE were significant higher than that of patients without MACCE （P 〈 0.001 ）. COX regression analysis denied sVCAM-1 as an independent prognostic factor. Conclusion Our data suggest that sVCAM-1 may be associated with ACS risk, and it might serve as a biomarker for predicting ACS prognosis.

关 键 词：急性冠脉综合征 VCAM-1 ICAM-1 预后 

分 类 号：R54[医药卫生—心血管疾病]