红景天苷与酪醇在大鼠体内的药动学研究  

Research on pharmacokinetics of salidroside and tyrosol in rats

作　　者：林俊芝 张定堃[2] 邹亮[3] 杨金辉[2] 段渠[1] 

机构地区：[1]成都中医药大学附属医院,四川成都610072 [2]成都中医药大学药学院,四川成都611137 [3]成都大学生物产业学院,四川成都610106

出　　处：《中成药》2014年第9期1845-1849,共5页Chinese Traditional Patent Medicine

基　　金：国家自然科学基金资助项目(81403115)

摘　　要：目的建立HPLC法同时测定大鼠血浆中红景天苷和酪醇,研究其在大鼠体内的药动学特征。方法大鼠灌胃给予红景天苷药液和酪醇药液,于不同时间点眼眶取血,采用HPLC法测定血样中的药物浓度,血药浓度-时间曲线经DAS 2.0软件进行房室模型拟合并计算和比较各组药动学参数。结果红景天苷和酪醇在大鼠体内的代谢过程均符合二室模型,权重w=1/cc。大鼠灌胃给予红景天苷30、50、100 mg/kg 3种剂量后的tmax均为0.5 h,t1/2z分别为(1.45±0.29)h、(2.02±0.87)h、(0.96±0.16)h,AUC0-t分别为(8.61±0.10)mg·h/L、(9.28±1.12)mg·h/L、(26.06±8.67)mg·h/L。大鼠灌胃给予酪醇30、50、100 mg/kg 3种剂量后的tmax均为0.083 h,t1/2z分别为(0.52±0.22)h、(0.56±0.42)h、(0.59±0.37)h,AUC0-t分别为(26.17±1.27)mg·h/L、(28.63±0.42)mg·h/L、(68.08±6.68)mg·h/L。结论红景天苷与酪醇在大鼠体内的吸收与消除均较快。AIM To establish an HPLC method to determine rat plasma concentrations of salidroside and ty- rosol （ both were active ingredients found in Rhodiola crenulata （ Hook. f. et Thorns. ） ） simultaneously, and to expose their pharmacokinetics characteristics. METHODS Blood samples were collected via orbit vein at fixed time intervals after intragastric administration of salidroside and tyrosol. The plasma concentrations of the two sub- stances were determined by HPLC. The data were processed by the software of DAS2. 0. RESULTS Both salidro- side and tyrosol were best fitted to the two-compartment open pharmacokinetic model with weight coefficient w of 1/ cc. After intragastric administration of 30, 50 and 100 mg/kg of salidroside, tmax in three groups was 0. 5 h; tl/2z were （1.45 ±0.29） h, （2. 02 ±0.87） h, and （0. 96 ±0. 16） h, respectively; and AUC0-t were （8.61 ±0. 10） mg · h/L, （9. 28 ±1.12） mg · h/L, and （ 26. 06 ± 8.67 ） mg · h/L , respectively. The parameters gained after the intragastric use of the same dose of tyrosol were： tmax 0. 083 h; tl/2z （0. 52 ±0. 22） h, （0. 56 ±0. 42） h, and （0.59 ±0.37） h, respectively; and AUC0-t（26.17±1.27） mg · h/L, （28.63 ±0.42） mg · h/L, and （68.08 ± 6. 68） mg · h/L, respectively. CONCLUSION Both salidroside and tyrosol are quickly absorbed and rapidly eliminated in rats.

关 键 词：红景天苷 酪醇 药动学 大鼠 

分 类 号：R969.1[医药卫生—药理学]