铜陵地区医院感染病原菌分布及耐药性分析  

Distribution and drug resistance of pathogens causing nosocomial infections in Tongling district

作　　者：洪洲[1] 潘晓龙[1] 林荣[1] 

机构地区：[1]铜陵市人民医院感染管理科,安徽铜陵244000

出　　处：《中华医院感染学杂志》2014年第18期4434-4435,4444,共3页Chinese Journal of Nosocomiology

基　　金：铜陵市卫生局基金资助项目(TW-2010B10037)

摘　　要：目的研究铜陵地区医院感染的病原菌分布及其耐药性,为临床治疗提供参考依据。方法选取2009年1月-2013年1月铜陵地区的1 200例住院患者,分别采集其痰液、脓液、伤口分泌物、尿液、血液等进行细菌培养,并用全自动分析仪鉴定菌种,采用纸片扩散法进行药敏试验及耐药性分析。结果共分离病原菌830株,其中革兰阴性菌462株占55.66%,以大肠埃希菌、铜绿假单胞菌、肺炎克雷伯菌为主,革兰阳性菌368株占44.34%,以金黄色葡萄球菌、凝固酶阴性葡萄球菌为主;革兰阴性菌普遍对亚胺培南敏感,耐药率<10.00%,对其他抗菌药物均有不同程度的耐药性;革兰阳性菌普遍对万古霉素、替考拉宁敏感,耐药率均为0,而对其他抗菌药物呈现不同程度的耐药。结论铜陵地区医院感染病原菌以革兰阴性菌为主,除少数抗菌药物外,病原菌对多数抗菌药物呈现不同程度的耐药,因此需要对抗菌药物的临床应用进行规范指导。OBJECTIVE To study the distribution and drug resistance of pathogens causing nosocomial infections in Tongling district so as to provide guidance for clinical treatment .METHODS A total of 1 200 patients who were hospitalized in Tongling district from Jan 2009 to Jan 2013 were enrolled in the study ,then the sputum ,pus , wound secretions ,urine ,and blood were collected for bacterial culture ,the species of pathogens were identified by using automatic analyzer ,and the drug susceptibility testing was performed with the use of disk diffusion method . RESULTS Totally 830 strains of pathogens have been isolated ,including 462 （55 .66% ） strains of gram-negative bacteria and 368 （44 .34% ） strains of gram-positive bacteria ;the Escherichia coli ,Pseudomonas aeruginosa ,and K lebsiella pneumoniae were the predominant species of gram-negative bacteria ;the Staphylococcus aureus and co-agulase-negative Staphylococcus were dominant among the gram-positive bacteria .The drug resistance rates of the gram-negative bacteria to imipenem were less than 10 .00% ,and the strains varied in the drug resistance to other antibiotics ;the drug resistance rates of the gram-positive bacteria to vancomycin and teicoplanin were 0 ,and the strains varied in the drug resistance to other antibiotics .CONCLUSION The gram-negative bacteria are the predom-inant pathogens causing nosocomial infections in Tongling district .The pathogens vary in the drug resistance to the majority of antibiotics ,therefore ,it is necessary to standardize the clinical use of antibiotics .

关 键 词：铜陵地区 医院感染 病原菌 耐药性 

分 类 号：R378[医药卫生—病原生物学]