妊娠梅毒孕妇不同药物治疗效果研究  

Study on anti-syphilis therapy for pregnant syphilis

作　　者：张长英[1] 徐东萍[1] 梁萍[1] 丁超英[1] 

机构地区：[1]浙江省新昌县人民医院妇产科,浙江新昌县312500

出　　处：《中华医院感染学杂志》2014年第18期4463-4465,共3页Chinese Journal of Nosocomiology

基　　金：浙江省医药卫生科技基金资助项目(2013KYB272)

摘　　要：目的探讨不同时机及不同药物治疗妊娠梅毒孕妇对足月妊娠分娩率、早产率、死胎率、低体质量儿发生率、畸形率及产妇与新生儿快速血浆反应素环状卡片试验(RPR)滴度的影响。方法选择2006年2月-2012年12月住院分娩治疗的妊娠梅毒孕妇160例为研究对象,将其随机分为4组,每组40例,并对4组孕妇的足月妊娠分娩率、早产率、死胎率、低体重儿发生率、畸形率及产妇与新生儿RPR滴度进行检测及比较;A、B、C 3组治疗组孕妇中应用苄星西林、头孢曲松、阿奇霉素治疗,观察治疗后新生儿结局比较,数据采用SPSS12.0统计软件进行处理。结果足月分娩率A组为90.0%、D组为40.0%,A组的早产率、死胎率低体重儿发生率及畸形率分别为10.0%、0.0%、10.0%及0,D组分别为30.0%、30.0%、30.0%及20.0%,差异均有统计学意义(P<0.05);A组中≤12周治疗组母婴RPR滴度<1∶8明显多于其他组,差异有统计学意义(P<0.05);新生儿先天梅毒发生率应用苄星西林治疗组为13.6%,应用头孢曲松治疗组为20.0%,两组比较,差异无统计学意义,阿奇霉素治疗组新生儿先天梅毒发生率为66.7%,与其他两组发生率比较,差异有统计学意义(P<0.05)。结论早期的抗梅治疗及正规的青霉素治疗对改善妊娠梅毒的预后有着重要的意义,因此主张早期治疗及首选青霉素治疗。OBJECTIVE To discuss the effects of the timing and medication treatment for pregnancy syphilis on patients′prognosis of the full-term delivery rates ,premature delivery rates ,fetal death rates ,occurrences of low weight infants ,deformity rates ,and titers of RPR of mothers and infants .METHODS From Feb .2006 to Dec . 2012 ,160 cases of pregnant syphilis treated in our hospital were chosen for this study . They were randomly divided into four groups （40 cases in each group ）：group A ,B ,C and D . The four groups were detected and compared with respect to full-term delivery rates ,premature delivery rates ,fetal death rates ,occurrences of low weight infants ,deformity rates and titers of RPR of mothers and infants .The three treatment groups （A ,B and C） of pregnant women were treated respectively with benzathine penicillin , ceftriaxone and azithromycin . A comparison was made among the three groups about the infants′ prognoses .Data collected were processed with SPSS12 .0 .RESULTS The study found that ,the full-term delivery rate was 90 .0% in group A and 40 .0% in group D ;the premature delivery rate ,fetal death rate ,occurrence of low weight infants ,and deformity rate was 10 .0% ,0 .0% ,10 .0% and 0 .0% respectively in group A ,and 30 .0% ,30 .0% ,30 .0% and 20 .0% respectively in group D ,which showed a significant difference （P〈0 .05） .The titers of RPR of mothers and infants 〈1∶8 of group A （≤ 12 weeks of treatment） was significantly higher than those of the other groups （P〈 0 .05） .The occurrence rate of congenital syphilis in the infants was 13 .6% in the group treated with benzathine penicillin ,and was 20% in the group treated with ceftriaxone ,which showed no significant difference .The occurrence rate of congenital syphilis in the infants was 66 .7% in the group treated with the azithromycin , which showed a statistically significant difference （P〈0 .05） ,compared to the other two treatment groups .CONCLUSIONS Early anti-syphilis therapy and benzathine pen

关 键 词：妊娠梅毒 疗效 研究 

分 类 号：R978.1[医药卫生—药品]