幽门螺杆菌感染与胃食管反流病的相关性研究  

Correlation between Helicobacter pylori infection and gastroesophageal reflux disease nocturnal acid breakthrough

作　　者：尚品杰[1] 柳静 

机构地区：[1]南阳市中心医院消化内科二病区 [2]南阳市理工学院,河南南阳473003

出　　处：《中华医院感染学杂志》2014年第18期4531-4533,共3页Chinese Journal of Nosocomiology

基　　金：河南省卫生厅基金资助项目(NW-2010B108)

摘　　要：目的观察分析幽门螺杆菌感染与胃食管反流病夜间酸突破的相关性研究,以提高胃食管反流病的治疗效果。方法选取2011年3月-2012年3月收治的胃食管反流病患者共140例,随机将患者分为观察组和对照组两组,各70例,观察组患者采用幽门螺杆菌根治术;对照组不采取幽门螺杆菌根治法;记录两组患者夜间酸突破的情况,记录患者22∶00到次日8∶00的夜间酸突破情况,同时测定患者的胃酸pH值。结果对照组患者夜间酸突破的发生率显著减少,其中对照组的发生率为32.9%,明显要低于观察组的52.9%,两组比较差异有统计学意义(P<0.05);两组患者的胃内pH变化、食管反流症状评分对比差异均无统计学意义;对照组患者治疗前后对比差异有统计学意义(P<0.05),说明患者食管反流症状有所缓解;观察组患者治疗前后对比,差异无统计学意义。结论幽门螺杆菌感染会降低胃食管反流病夜间酸突破的发生,两者之间有一定的相关性。OBJECTIVE To observe the relationship between the Helicobacter pylori infection and gastroesophageal reflux disease nocturnal acid breakthrough so as to improve the curative effect of gastroesophageal reflux disease . METHODS A total of 140 patients with gastroesophageal reflux disease who were treated from Mar 2011 to Mar 2012 were enrolled in the study and randomly divided into the observation group and the control group ,with 70 ca-ses in each group ;the observation group was treated with radical surgery for H .pylori ,while the control group was not given the radical surgery ;the nocturnal acid breakthroughs were recorded , the nocturnal acid break-throughs were recorded from 22：00 to 8 ：00 of next day ,and the pH value of gastric acid was determined . RESULTS The incidence of nocturnal acid breakthroughs of the control group was 32 .9% ,significantly lower than 52 .9% of the observation group（P〈0 .05）;there was no significant difference in the change of gastric pH or e-sophageal reflux symptom score between the two groups ;however ,there was significant difference in the change of gastric pH or esophageal reflux symptom score of the control group between before and after treatment （P〈0 .05） ,indicating that the esophageal reflux symptom has recovered to a certain degree ;there was no significant difference in the observation group between before and after treatment .CONCLUSION The H .pylori infection may contribute to the reduction of incidence of gastroesophageal reflux disease nocturnal acid breakthrough ,and there is certain correlation between the two .

关 键 词：幽门螺杆菌感染 胃食管反流病 夜间酸突破 

分 类 号：R181.32[医药卫生—流行病学]