糖尿病与非糖尿病患者尿路感染的临床对比研究  

Clinical comparative study of urinary tract infections in diabetic and non-diabetic patients

作　　者：郭业新[1] 赵红强[1] 张凤梅[1] 

机构地区：[1]莱芜市人民医院内分泌科,山东莱芜271199

出　　处：《中华医院感染学杂志》2014年第18期4537-4539,共3页Chinese Journal of Nosocomiology

基　　金：莱芜市科研基金资助项目(莱科鉴字2010-122)

摘　　要：目的探讨糖尿病与非糖尿病患者尿路感染在临床表现、病原菌分布及药敏结果的差异性,以期提高临床诊治水平。方法选取2009年4月-2012年3月29例糖尿病尿路感染患者为研究对象,将其作为观察组,另选同期36例尿路感染无糖尿病患者作为对照组,对比分析两组患者在临床表现、病原菌分布及药敏结果的差异性。结果糖尿病尿路感染无临床症状占51.72%;观察组分离出病原菌37株,排前3位的病原菌为大肠埃希菌、铜绿假单胞菌、粪肠球菌,分别占54.05%、13.51%、10.81%,对照组分离出病原菌49株,排前3位的是大肠埃希菌、耐甲氧西林固酶阴性葡萄球菌、肺炎克雷伯菌,分别占48.98%、18.37%、12.24%;观察组患者检出大肠埃希菌对亚胺培南、头孢米诺、头孢哌酮/舒巴坦耐药率较低,<15.00%;对照组检出大肠埃希菌对氨曲南、头孢哌酮/舒巴坦耐药率较低,<16.67%。结论糖尿病尿路感染无症状性菌尿较常见,住院时间长、治愈率低,临床上要重视对尿液的培养,选择敏感抗菌药物。OBJECTIVE To investigate differences in clinical manifestations , pathogen distribution and drug susceptibility results of urinary tract infection between diabetic and non-diabetic patients so as to improve clinical diagnosis and treatment .METHODS Totally 29 diabetic patients with urinary tract infection from Apr .2009 -Mar .2012 were selected as the research subjects in the observation group ,and another 36 diabetic patients without urinary tract infection during the same period were selected as the control group .Differences of two groups in the clinical manifestations ,pathogens and susceptibility results were compared and analyzed .RESULTS Diabetic patients with urinary tract infection who had no clinical symptoms accounted for 51 .72% . In the observation group ,thirty-seven strains of pathogens were isolated from the patients ,and pathogens ranking the first three were Escherichia coli , Pseudomonas aeruginosa and Enterococcus f aecalis ,accounting for 54 .05% , 13 .51% ,and 10 .81% ,respectively .In the control group ,49 strains of pathogens were isolated ,and pathogens ranking the first three were E . coli , methicillin-resistant immobilization enzyme-negative Staphylococcus and K lebsiella pneumoniae ,accounting for 48 .98% ,18 .37% ,and 12 .24% .In the observation group ,E .coli had a relatively low resistance to imipenem , cefminox , and cefoperazone/sulbactam , all 〈 15 .00% . In the control group , E . coli had a relatively low resistance to aztreonam , and cefoperazone/sulbactam , all 〈 16 .67% . CONCLUSION Urinary tract infection in diabetes is commonly asymptomatic with long hospital stay and low cure rate .Attention should be paid in clinical treatment ,and sensitive antibiotics should be selected .

关 键 词：糖尿病 非糖尿病 尿路感染 病原菌 

分 类 号：R691.3[医药卫生—泌尿科学]