颅脑外伤患者鼻咽部感染对预后影响的研究  

Effect of nasopharyngeal infections on prognosis of patients with traumatic brain injury

作　　者：刘光辉[1] 王国琴 肖平 

机构地区：[1]山东省临朐县人民医院脑外科 [2]耳鼻喉科 [3]中医院妇科,山东临朐县262600

出　　处：《中华医院感染学杂志》2014年第18期4550-4551,4554,共3页Chinese Journal of Nosocomiology

基　　金：国家自然科学基金资助项目(30864573)

摘　　要：目的探讨颅脑外伤患者对鼻咽部感染预后的影响,为其预后提供参考依据。方法选取2009年12月-2012年6月收治的颅脑外伤的患者125例,按照有无鼻咽部感染将患者分为感染组和非感染组,其中感染组45例,非感染组80例,观察两组患者预后及相关并发症。结果两组患者预后按照格拉斯哥昏迷评分法(GCS评分),感染组恢复良好、轻残、重残、植物生存状态、死亡分别占24.44%、33.33%、22.22%、8.89%、11.11%,非感染组分别占45.00%、32.50%、15.00%、1.25%、6.25%,两组患者预后相比,差异有统计学意义(P<0.05);住院期间鼻咽部感染患者使用抗菌药物的剂量显著高于非感染组,两组比较差异有统计学意义(P<0.05),感染组使用抗菌药物天数为(14.5±3.5)d,非感染组为(6.7±3.3)d,两组比较差异有统计学意义(P<0.05);随访1年后,感染组患者出现颅内感染的概率显著高于非鼻咽部感染组,两组比较差异有统计学意义(P<0.05)。结论鼻咽部感染严重影响颅脑外伤患者的预后及生存,为影响颅脑外伤患者预后的独立危险因素。OBJECTIVE To study the effect of nasopharyngeal infection on the prognosis of patients with traumatic brain injury so as to provide reference for prognosis of patients with traumatic brain injury .METHODS Totally 125 patients with traumatic brain injury from Dec .2009 to Jun .2012 in our hospital were studied .Patients were divided into the infection group （n= 45） and the non-infection group （n= 80） according to the situation of nasopharyngeal infection .Prognosis and related complications were observed .RESULTS Prognosis was evaluated according to Glasgow coma score （GCS score） .The infection group had good recovery in 11 cases （24 .44% ） , mild disability in 15 cases （33 .33% ） ,severe disability in 10 cases （22 .22% ） ,plant survival in 4 cases （8 .89% ） , and deaths in 5 cases （11 .11% ） .The non-infected group had good recovered in 36 cases （45 .00% ） ,mild disability in 26 cases （32 .50% ） ,severe disability in 12 cases （15 .00% ） ,plant survival in 1 case （1 .25% ） ,and deaths in 5 cases （6 .25% ） .Comparison of prognosis between two showed a significant difference （P〈 0 .05） . During treatment ,antibiotic dose and the use of time were much higher in the infection group than in the non-in-fection group ,the difference was significant （P〈0 .05） .The duration of antibiotic use was （14 .5 ± 3 .5） d in the infection group and （6 .7 ± 3 .3） d in the non-infection group ,the difference was significant（P〈0 .05） .After 1 year follow-up ,the incidence of intracranial infection was significantly higher in the infection group than in the non-infection group（P〈0 .05） .CONCLUSION Nasopharyngeal infection severely affects prognosis and survival of patients with traumatic brain injury which is an independent risk factor affecting the prognosis of patients with traumatic brain injury .

关 键 词：颅脑外伤 鼻咽部 感染 预后 

分 类 号：R181.32[医药卫生—流行病学]