血清与脑脊液中炎性因子检测对颅内感染早期诊断的临床意义  

Study on clinical significance of inflammatory cytokines in serum and cerebrospinal fluid testing for early diagnosis of intracranial infection

作　　者：孙桂好 孙宏亮[1] 王海鹏[1] 

机构地区：[1]安丘市人民医院神经外一科,山东安丘262100

出　　处：《中华医院感染学杂志》2014年第18期4665-4667,共3页Chinese Journal of Nosocomiology

基　　金：山东省自然科学基金资助项目(Y2008C025)

摘　　要：目的探讨血清和脑脊液中炎性因子检测在颅内感染早期诊断中的临床意义,为颅内感染早期的治疗提供理论依据。方法选取2010年12月-2012年12月收治的60例颅内感染患者作为研究对象,并选择同期住院的非颅内感染患者30例作为对照,分别采用ELISA法检测两组受试者血清和脑脊液中炎性因子C-反应蛋白(CRP)、干扰素-α(TNF-α)和白介素-6(IL-6)的变化以及对不同阶段颅脑感染患者血清和脑脊液中炎性因子相关指标的改变情况,并进行对比分析。结果颅内感染组患者血清中CRP、TNF-α和IL-6显著高于非颅内感染组,两组比较差异有统计学意义(P<0.05);化脓性脑膜炎患者血清CRP、TNF-α和IL-6分别高于对照组、病毒性脑膜炎以及结核性脑膜炎患者,差异有统计学意义(P<0.05);颅内感染组患者随着发病时间的延长,其血清中CRP、TNF-α和IL-6逐渐增高,组间比较差异有统计学意义(P<0.05)。结论颅内感染患者血清及脑脊液中炎性因子显著高于非颅内感染患者,且随着疾病的进展,其浓度随之增加,对颅内感染的早期诊断及判断病情有着极其重要的作用。OBJECTIVE To study the clinical significance of inflammatory cytokines in serum and cerebrospinal fluid testing for early diagnosis of intracranial infection so as to provide a theoretical basis for treatment of early intracranial infection .METHODS Totally 60 patients with intracranial infection from Dec .2010 to Dec .2012 in our hospital were studied .And 30 patients with no intracranial infection during the same period were chosen as the control group .Subjects were detected by ELISA for changes in inflammatory cytokines C-reactive protein （CRP） , TNF-αand IL-6 in serum and cerebrospinal fluid ,as well as changes in relevant indicators of inflammatory cytokines in different stages of brain infection ,and the comparative analysis was conducted .RESULTS Serum CRP ,TNF-α and IL-6 in the intracranial infection group were significantly higher than in the non-intracranial infection group ,the difference was significant （P〈0 .05） .Serum CRP ,TNF-αand IL-6 in patients with purulent meningitis were significantly higher than in patients in the control group and patients with viral meningitis and tuberculous meningitis（P〈0 .05） .And serum CRP ,TNF-αand IL-6 increased gradually with the prolong of on-set time in the group of patients with intracranial infection ,the difference was significant between groups （P〈0 .05） .CONCLUSION Inflammatory cytokines in serum and cerebrospinal fluid in patients with intracranial infec-tion are significantly higher than in patients without intracranial infection ,and as the disease progresses ,the con-centration increases ,which has an extremely important role for the early diagnosis of intracranial infection and the condition determination .

关 键 词：颅内感染 炎性因子 C-反应蛋白 

分 类 号：R446[医药卫生—诊断学]