槐角黄酮栓抗炎、止血、抗溃疡作用的实验研究  

Study on Anti-Inflammatory, Hemostasis and Anti-Ulcerative Effects of Fructus Sophorae Flavonoids Suppository

作　　者：王永红[1] 冉茂娟[1] 姜艳[2] 王剑波[2,3] 曾成鸣[3] 

机构地区：[1]重庆医科大学附属永川医院老年病科,重庆402160 [2]第四军医大学药学院天然药物学教研室,陕西西安710032 [3]陕西师范大学化学化工学院,陕西西安710062

出　　处：《现代生物医学进展》2014年第27期5247-5252,共6页Progress in Modern Biomedicine

基　　金：陕西省中医药管理局基金课题(2009ZY015)

摘　　要：目的:研究槐角黄酮栓的抗炎、止血、抗溃疡作用。方法:从中药槐角中提取总黄酮,与脂肪酸甘油酯混合后用热融法制成栓剂。采用小鼠耳廓肿胀法、滤纸肉芽肿法、腹腔毛细血管通透性试验和角叉菜胶致大鼠足跖肿胀法观察槐角黄酮栓的抗炎作用;通过玻璃毛细管法和断尾法测定小鼠出、凝血时间,评价槐角黄酮栓的止血效果。复制大鼠直肠损伤模型,直肠给药治疗,观察伤口愈合情况并HE染色,评价槐角黄酮栓的促愈合作用。结果:槐角黄酮栓具有明显的抗炎、抗溃疡作用,并能缩短小鼠出、凝血时间,提高直肠创面愈合率。结论:槐角黄酮栓制备工艺简单,具有较好的抗炎、止血、抗溃疡作用。Objective： To study the effect of Fructus Sophorae Flavonoids Suppository（FSFS） on anti-inflammator, hemostasis and anti-ulcerative. Methods： The total flavones was extracted from Chinese traditional medicine Fructus Sophorae, which was mixed with adeps solidus to prepare the suppository by the method of hot-melting. The anti-inflammatory effects of FSFS were determined by using the experiment of swelling of ear induced by xylene, granuloma induced by cotton ball, capillary permeability of abdominal cavity induced by acetic acid and hind paw edema induced by carrageenin in mice. The hemostatic efficacy of FSFS and the coagulation time were measured by the glass capillary method, and the bleeding time was measured by the tail-cutting method, respectively. Rat anorectal wound model was established, and the healing effect of FSFS was evaluated by HE staining. Results： The FSFS has distinct anti-inflammatory, anti-ulcerative effects, as well as obviously shorten the coagulation time and bleeding time of mice severed tail, and increase anorectal wound healing proportion. Conclusion： Preparation process of FSFS is simple, and showed good anti-inflammatory,hemostasis and anti-ulcerative effects.

关 键 词：槐角 总黄酮 栓剂 抗炎 止血 抗溃疡 

分 类 号：R286[医药卫生—中药学] R965[医药卫生—中医学]