髓系细胞触发受体-1研究进展  

Development of Triggering Receptor Expressed on Myeloid Cells-1

作　　者：汪学翠 刘红梅[1] 陈思文[1] 付婷[1] 王翎[1] 

机构地区：[1]苏州大学附属第一医院特需病区,江苏苏州215006

出　　处：《现代生物医学进展》2014年第27期5387-5390,5364,共5页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(30330540)

摘　　要：髓系细胞表达的触发受体1(triggering receptor expressed on myeloid cells-1,TREM-1)是主要表达于巨噬细胞、中性细胞等的表面受体蛋白,它属于免疫球蛋白超家族的成员,主要由赖氨酸残基的跨膜结构域、V型Ig样胞外结构域和缺乏信号基序的胞浆结构域等三个部分组成。TREM-1分子在感染性疾病中发挥重要作用,通过其和细胞外受体蛋白DAP-12结合,引起下游信号通路活化,导致多种炎症介质的分泌,具有预激和诱导炎症反应的作用,对感染性疾病的诊断起到重要作用。但最近研究显示TREM-1不仅在感染性组织中表达增高,在非感染性炎症、结缔组织及肿瘤组织中也有增高表现,本文就TREM-1最新研究进展做一综述。Triggering receptor expressed on myeloid cells 1 is mainly expressed on the surface receptor proteins of macrophages and neutral, which belongs to superfamily of Immunoglobulin, It contains the membrane structure domain of lysine residues, the form of V extracellular domain structure and cytoplasm structure domain which is less than signal motif. TREM-1 plays an important role in the infectious disease, which combines with extracellular receptor proteins DAP - 12, cause downstream signaling pathway activation and the secretion of a variety of inflammatory mediators, pre-excitation syndrome and induced inflammation. It plays an important role in infectious diseases. The latest research suggests that TREM-1 is not only expressed in infectious diseases, but also belongs to non-infectious inflammation, connective tissue and tumor tissue. This text introduces the latest research progress of TREM-1.

关 键 词：髓系细胞表达的触发受体-1 炎症反应 肿瘤预后 

分 类 号：R55[医药卫生—血液循环系统疾病]