A型利钠肽与焦虑障碍相关性分析  

Correlation analysis of A type natriuretic peptide and anxiety disorders

作　　者：王旭 何薇[2] 王强[2] 雷鸣[3] 

机构地区：[1]成都市武侯区望江路社区卫生服务中心,成都610041 [2]成都中医药大学,成都610075 [3]成都中医药大学附属医院,成都610072

出　　处：《长春中医药大学学报》2014年第4期726-728,共3页Journal of Changchun University of Chinese Medicine

基　　金：国家自然科学基金项目(81173322)

摘　　要：现代研究提示,利钠肽是一种具有抗焦虑、抗恐慌等情绪疾病的神经调节剂,其中A型利钠肽最为重要。心脏方面,焦虑障碍患者中血浆ANP水平往往低于正常,增加其含量则可达到抗焦虑作用;中枢方面,焦虑障碍发生时HPA轴功能亢进,而A型利钠肽对HPA轴有良性的调节作用。推测A型利钠肽及其受体的功能异常可能是焦虑障碍发病的重要机制之一。探索这一机制有助于进一步完善焦虑障碍的病理生理机制。Recent studies indicated that natriuretic peptide is a kind of antipanic and anxiolytic neuroregulator, especially the A type natriuretic peptide. In cardiovascular system, the levels of ANP in plasma of patients with anxiety disorders are often lower than normal, but the increase of ANP level can reach anti-anxiety effect; In central nervous system,HPA axis becomes overactive while anxiety disorders occur, A type natriuretic peptide can paly a role of benignly adjust the HPA axis＇ function. It is easy to infer that one of the important mechanism of anxiety disorder perhaps is the dysfunction of A type natriuretic peptide and its receptor. The exploration of the mechanism will be good for further improving the physiopathologic mechanism of anxiety disorders.

关 键 词：A型利钠肽 焦虑障碍 神经调节剂 抗焦虑 

分 类 号：R256.28[医药卫生—中医内科学]