红细胞分布宽度与慢性阻塞性肺疾病继发肺动脉高压的相关性研究  

The relationship between red blood cell distribution width and pulmonary hypertension secondary to chronic obstructive pulmonary disease

作　　者：王金艳[1] 洪波[2] 孙珍贵[1] 陆志伟[1] 程玉生[1] 

机构地区：[1]皖南医学院第一附属医院呼吸科,芜湖241001 [2]安徽省庐江县人民医院外科 ,231500

出　　处：《国际呼吸杂志》2014年第17期1301-1303,共3页International Journal of Respiration

摘　　要：目的探讨红细胞分布宽度（RDW）与COPD继发肺动脉高压相关性。方法回顾性分析2012年9月至2013年10月期间入住皖南医学院第一附属医院呼吸科病房COPD的患者临床资料。根据入选标准及排除标准，将72例入选病例分为肺动脉压正常组和增高组，比较两组一般情况、基础疾病情况、RDW和住院时间。结果肺动脉压增高组RDW明显高于肺动脉压正常组RDW[15．98±1．78）％VS（14．46±1．36）％]，差异具有统计学意义（P〈0．001）。而年龄、性别、高血压、糖尿病、冠状动脉粥样硬化性心脏病、血红蛋白、PaO2、PaCO2及住院时间两组之间差异均无统计学意义。Pearson相关性分析结果示RDW与肺动脉高压呈正相关，差异具有统计学意义（r=0．577，P=0．01）。结论在COPD继发肺动脉高压患者体内RDW明显增高，并与肺动脉高压严重程度呈正相关。RDW可作为反应COPD继发肺动脉高压严重程度的有用指标。Objective To explore the relationship between red blood cell distribution width and pulmonary hypertension secondary to chronic obstructive pulmonary disease （COPD）. Methods Retrospective analysis the clinical data of inpatients with COPD in the first affiliated hospital of Wannan medical college during September 2012 and October 2013. According to the inclusion criteria and exclusion criteria, 72 cases were divided into pulmonary hypertension group and normal pulmonary artery pressure group. General condition, underlying diseases situation, RDW and length of stay were compared between two groups. Results RDW of pulmonary hypertension was significantly higher than that of the normal pulmonary artery pressure group, （ 15.98 ±1.78） % vs （ 14.46 ± 1.36） %, respectively, which shared with significant statistical difference （ P 〈 0.001 ）. However, the age, sex, hypertension, diabetes, coronary heart disease,hemoglobin,PaO2, PaCO2 and length of hospital stay of pulmonary hypertension group had no statistical difference with that of normal pulmonary artery pressure group. Pearson correlation analysis showed that RDW had a positively significant correlation with pulmonary hypertension （ r =0. 577, P = 0.01）. Conclusions RDW increases significantly in pulmonary hypertension secondary to COPD patients. RDW shared positive correlation with the severity of pulmonary hypertension. RDW may be used as a useful index to reflect the severity of pulmonary hypertension secondary to COPD.

关 键 词：红细胞分布宽度 慢性阻塞性肺疾病 肺动脉高压 

分 类 号：R563.9[医药卫生—呼吸系统]