吸烟引起慢性阻塞性肺疾病糖皮质激素抵抗的机制及应对策略  

Mechanism and countermeasures of glucocorticoid resistance caused by smoking in patients with COPD

作　　者：刘琛琛[1] 高兴林[2] 

机构地区：[1]南方医科大学,广州510515 [2]广东省人民医院呼吸内科,广州510080

出　　处：《国际呼吸杂志》2014年第17期1334-1337,共4页International Journal of Respiration

摘　　要：糖皮质激素（GC）在大部分支气管哮喘患者的治疗中取得了显著的疗效，然而对大多数COPD患者疗效欠佳。COPD发病的核心环节是慢性炎症反应，GC是体内最强大最广谱的抗炎物质，当GC对炎症反应的抑制作用下降，会导致炎症反应的持续，从而引起相应病理过程。因此，激素抵抗不仅仅是COPD患者治疗不佳的原因，它有可能直接参与了COPD的发病。本文对吸烟所致COPD引起GC抵抗的机制及目前可能采取的对策进行综述。Glucocorticoids are the most effective therapy for most of bronchial asthma patients yet are relatively ineffective in COPD. Chronic inflammation plays a very important role in the pathogenesis of COPD,reduced responsiveness to the anti-inflammatory effects of glucocorticoids which are the most powerful anti-inflammation inside the body will maintain inflammation. Therefore corticosteroid resistance is not only the cause of poor efficacy in COPD but also the pathogenesis. This review aims to summarize the mechanisms and countermeasures of glucocorticoid resistance caused by smoking in patients with COPD.

关 键 词：糖皮质激素 抵抗 慢性阻塞性肺疾病 

分 类 号：R563.9[医药卫生—呼吸系统]