钛种植体表面构筑多级微/纳米活性结构的研究  

The Study of Constructing Micro/Nano-bioactive Structure on Titanium Implant Surface

作　　者：王世强[1] 陈艳文[1] 王周成[1] 

机构地区：[1]厦门大学化学化工学院,福建厦门361005

出　　处：《厦门大学学报（自然科学版）》2014年第5期726-731,共6页Journal of Xiamen University：Natural Science

基　　金：福建省经贸委企业技术创新基金

摘　　要：经喷砂的钛基体在H2SO4和HCl混合溶液中进行酸蚀,随后在HF溶液中恒电压下进行阳极氧化,构筑具有多级微/纳米复合结构膜层,并对不同表面处理样品进行体外实验,观察其生物活性.利用扫描电子显微镜（SEM）、能谱色散仪（EDS）及X射线衍射仪（XRD）表征其表面形貌、化学组成及晶型.结果表明,采用喷砂酸蚀,钛表面形成10~20μm喷砂凹陷及5~8μm酸蚀坑构成两级微米级结构,阳极氧化构造出10nm左右的纳米级第3级结构.体外实验显示,多级微/纳米复合结构样品相对于对照组具有更好的生物活性.通过表面多级结构的构筑及热处理,钛种植体的亲水性和生物活性均有较大幅度的提高.Multi-level micro/nano-structure on titanium surface was constructed by Al2O3 sandblasting and acid etching in H2 SO4 and HCl solution,and then anodizing in HF solution at a constant potential. The biological activities of different treated titanium sam- ples were observed in vitro experiments. Scanning electron microscopy （SEM）, energy disperse spectroscopy （EDS） and X-ray diffraction （XRD） were employed to characterize the morphology, composition, and crystalline phase of the different treated titanium samples. The results showed a multi-level micro/nano-composite structure consisting of hollows of 10-20μm diameter by sandblast, pits of 5-8 μm diameter by acid etching, and nanotexture of 10 nm diameter by anodizing. The results of vitro experiments showed that the multi-level micro/nano-composite structure had a higher biological activity than the control group. After modification and heating treatment of the surface,the sample with the multi-level micro/nano-composite structure showed excellent hydrophilic property and increased biological activity.

关 键 词：喷砂 酸蚀 阳极氧化 微 纳米结构 钛种植体 生物活性 

分 类 号：O614[理学—无机化学]