观察当归补血汤组方抑制荷瘤小鼠肿瘤生长的作用  

作　　者：岳斌[1] 张润莲[1] 王宝琴 刘冬彦 郝瑞 何晓华[1] 李维 

机构地区：[1]河北北方学院附属第-医院中医科,河北张家075000 [2]河北省张家口市崇礼县中医院,河北张家076350 [3]河北省张家口市崇礼县妇幼保健院,河北张家076350 [4]河北省张家口市沽源县医院,河北张家076550

出　　处：《中医学报》2014年第B07期17-17,共1页Acta Chinese Medicine

摘　　要：目的探究当归补血汤组方对荷瘤小鼠肿瘤的抑制作用.方法：选择的研究对象是 C57BL/6 小鼠总共48 只,将这些小鼠平均分成6 组,其中三组作为空白对照组,另外三组作为观察组.给予观察组老鼠当归补血汤组方,给予对照组老鼠生理盐水,查看小鼠的生存时间和肿瘤的大小.结果：观察组的肿瘤生长速度比空白对照组慢,C 组的肿瘤生长速度和空白对照组相比没有显著的差别.观察组的A 组、B 组小鼠存活时间明显比空白对照组长,C 组和空白对照组小鼠的存活时间没有明显的差异.空白对照组小鼠均在接种肿瘤的一个月内死亡,C 组小鼠在接种肿瘤31 天死亡,B 组小鼠在接种肿瘤的一个月后仍然有五分之四的小鼠存活,A 组小鼠在接种肿瘤的第30 天开始出现死亡现象,小鼠存活时间最长为46 天.结论：当归补血汤组方能够有效抑制荷瘤小鼠肿瘤生长,因此预防肿瘤应当使用当归补血汤组方.Objective To explore the inhibitory effect of Danggui Buxue Decoction on tumor bearing mice. Method： the subject is a total of 48 male C57BL/6 mice, these micewere divided into 6 groups, including three groups as blank control group, other three groups as the observation group. Given the observation group mouse Danggui Buxue Decoction,control group received normal saline for mice, the survival time of mice and the tumor size. Results： the group of tumor growth rate than the control group, group C slow, tumor growthspeed and no significant difference compared with the blank control group. Observation of A group, B group mice survival time was more than that in blank control group, C group andblank control group, the survival time of mice had no obvious difference. The mice in the blank control group all died within a month of inoculation of tumor in C mice inoculatedtumor, in 31 day mortality, B mice in one month after inoculation of tumor is still alive 4/5 mice, A mice inoculated tumor in thirtieth day mortality occurred, the mice survived thelongest time the 46 day. Conclusion： Danggui Buxue Decoction can effectively suppress tumor growth, thus preventing tumor should use the Danggui Buxue decoction.

关 键 词：当归补血汤 荷瘤小鼠肿瘤 抑制作用 

分 类 号：R28[医药卫生—中药学]