多药联合对500例髋关节置换术后深静脉血栓症状的预防研究  

Multi-drug combination of 500 cases with symptoms of deep veinthrombosis after hip replacement prevention research

作　　者：仇如来[1] 杜桂夏[1] 汪来杰[1] 张飞[1] 

机构地区：[1]江苏省洪泽县人民医院,江苏洪泽223100

出　　处：《中医学报》2014年第B07期154-155,共2页Acta Chinese Medicine

摘　　要：目的研究多药联合对500 例髋关节置换术后深静脉血栓症状的预防效果.方法：从2009 年2 月到2013 年2 月,于我院共有1000 例病患被诊断需行髋关节置换术.以数字法随机分成观察组（500 例）和对照组（500 例）.对两组患者举行髋关节置换术,观察组患者术后给予低分子肝素、低分子左旋糖酐、利伐沙班三种药物进行预防治疗,对照组患仅给予低分子肝素进行治疗.对比两组患者的预防效果、并发症等.结果：观察组疗效为优者占比66.40%（332/500）,优良率为97.00%（485/500）,均显著高于对照组的44.60%（223/500）,75.00%（375/500）.差异均有统计学意义（均P〈0.05）.观察组出血量为376.52±13.15ml,对照组的出血量为378.57±22.18ml,差异不具有统计学意义（P〉0.05）.观察组患者经彩色多普勒检查,估计栓块数量5.65±1.25 个,显著少于对照组的18.54±2.83 个.差异具有统计学意义（P〈0.05）.观察组患者出现凝血功能障碍5 例、全身性过敏3 例、转氨酶升高12 例、肌酐清除率降低3 例,均显著少于对照组的12 例、8 例、14 例、7 例.差异具有统计学意义（P〈0.05）.结论：多药联合对髋关节置换术后深静脉血栓症状的预防效果显著,安全性较高,不良反应少,优于单药治疗,值得在临床常规用药预防中广泛推广.objective： to study the multi-drug combination of 500 cases with symptoms of deep vein thrombosis after hip replacement prevention effect. Methods： fromFebruary 2009 to February 2013, a total of 1000 cases of patients in our hospital diagnosed to be hip replacement. In digital method randomly divided into observation group （500 cases）and control group （500 cases）. On two groups of patients with a hip replacement, the observation group of patients postoperatively low molecular heparin, low molecular sinistral sugaranhydride, cutting class three drugs for prevention and treatment, the control group with only give low molecular heparin for treatment. Comparison of two groups of patients withpreventive effect, complications, etc. Results： the observation group curative effect for instituting accounted for 66.40% （332/500）, fine rate was 97.00% （485/500）, 44.60% weresignificantly higher than that of control group （223/500）, 75.00% （375/500）. Are statistically significant differences （all P 〈 0.05）. Observation group the bleeding was 376.52 ＋ / - 13.15ml, control the bleeding was 378.57 ＋ / - 22.18 ml, no statistically significant difference （P 〉 0.05）. Observation group of patients by color doppler examination, estimate bolt blocknumber 5.65 ＋ / - 1.25, significantly less than 18.54 ＋ / - 2.83 in the control group. Statistically significant difference （P 〈 0.05）. Observation group appear in 5 cases, blood coagulationdysfunction in patients with systemic allergic 3 cases, 12 cases of transaminase eleations, reduced creatinine clearance （3 cases）, 12 cases were significantly less than in the controlgroup, 8 cases, 14 cases, 7 cases. Statistically significant difference （P 〈 0.05）. Conclusion： the combination of the multi-drug symptoms of deep vein thrombosis after hip replacementpreventive effect is remarkable, high safety, less adverse reaction, better than monotherapy and is worth popularizing widely in clinical routine drug prevention.

关 键 词：多药联合 髋关节置换 深静脉血栓 预防 

分 类 号：R687.4[医药卫生—骨科学]