B细胞在移植免疫中的调节作用  

The regulatory role of B cells in transplantation immunity

作　　者：秦瑶[1] 张梅[1] 

机构地区：[1]南京医科大学第一附属医院内分泌科,210029

出　　处：《国际免疫学杂志》2014年第5期386-389,共4页International Journal of Immunology

基　　金：国家自然科学基金（81070622;81370939）;江苏省六大人才高峰项目（2010-022）

摘　　要：传统认为,在移植免疫中B细胞作为抗原提呈细胞可加重T淋巴细胞介导的同种异体反应.但近期研究发现,某些B细胞亚群,如调节性B细胞（Bregs）具有免疫耐受性,在移植排斥反应中发挥负向调控作用,进而延缓同种异体移植排斥进程.因而研究B细胞在移植免疫中的调节作用,阐述B细胞发挥负向免疫调节机制及以B细胞为靶细胞的诱导移植耐受新策略具有重大意义.As antigen-presenting, B cells can aggravate T lymphocyte-mediated allograft reactions in transplantation immunity. However, recent studies have found that some B cell subsets, such as regulatory B cells （ Bregs）, have the character of immune tolerance and play a negative regulatory role in transplant rejection. Thus B cells delay the process of allograft rejection. This review will focus on the regulation of B lymphocyte in trans- plantation immunity,elaborate the negative immunoregulatory mechanisms of B cells and new immunotherapeutie strategies of induee transplantation tolerance with B cells as target cells.

关 键 词：B细胞 调节性B细胞 移植耐受 免疫治疗 

分 类 号：R392[医药卫生—免疫学]