归芍止痒颗粒质量标准研究  

Quality Control for Guishao Zhiyang Granule

作　　者：林以慈 何昭斌 孙虹[1] 何洋[1,2] 罗钧锦 石钺[1] 

机构地区：[1]中国医学科学院药用植物研究所,北京100193 [2]广州市悠好福医药科技有限公司,广东广州510610

出　　处：《中华中医药学刊》2014年第9期2182-2184,I0007,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：国家"重大新药创制"科技重大专项(2012ZX09301002 001)

摘　　要：目的:建立归芍止痒颗粒质量控制方法。方法:采用薄层色谱(TLC)法对组方中当归、川芎、地黄、丹参、苦参、地肤子进行定性鉴别;采用高效液相色谱(HPLC)法对芍药苷进行定量测定。结果:薄层色谱清晰,分离良好,阴性无干扰。芍药苷的平均回收率为98.99%,RSD为2.03%。结论:所建方法简便易行,灵敏准确,专属性强,可用于归芍止痒颗粒的质量控制。Objective： To establish the methods for quality control of Guishao Zhiyang Granule. Methods： Angelica sinensis, Ligusticum chuanxiongi, Rehmannia glutinous, Salvia miltiorrhiza, Sophora flavescens and Kochia scoparia were i- dentified by TLC. The contents of paeoniflorin were determined by HPLC. Results ： The spots from the test solutions on the thin layer plate were clear and the bland solution bad no interference. The average recovery of paeoniflorin was 98.99% （RSD 2.03% ）. Conclusion： The present method is simple and accurate with strong specificity and can be used to control the quality of Guishao Zhiyang Granule.

关 键 词：归芍止痒颗粒 薄层色谱 高效液相色谱 质量控制 

分 类 号：R284[医药卫生—中药学]