白花丹参水提物对糖尿病大鼠胰腺的保护作用  

Protective Effects of Salvia Miltiorrhiza Water Extract on Function and Pancreas of Diabetes Mellitus Rats

作　　者：辛燕[1] 李菁[2] 黄东辉[3] 

机构地区：[1]济南市中医医院,山东济南250012 [2]泰安市中医二院,山东泰安271000 [3]泰山医学院临床学院,山东泰安271016

出　　处：《中华中医药学刊》2014年第9期2232-2234,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：山东省中医药科技发展计划项目(2011-226)

摘　　要：目的:观察白花丹参水提物对实验性糖尿病大鼠胰腺功能的影响,明确其治疗作用。方法:以高糖高脂饮食喂养的90只雄性Wistar大鼠尾静脉注射链脲佐菌素(25 mg/kg)建立糖尿病(DM)模型,随机分为空白组、模型组、西药组、中药高,中,低剂量组,于给药第4周后测FPG、INSULIN、MDA、SOD等指标,进行统计分析。结果:与模型组相比,中药组、西药组对糖尿病模型大鼠血糖和胰腺均有显著的治疗作用,FPG、MDA明显降低,INSULIN、SOD明显升高,优于模型组(P<0.01);中药治疗组随剂量的增加,效果显著增加,而以中药大剂量组效果最好,明显优于其他各组(P<0.01)。结论:白花丹参水提物对糖尿病大鼠胰腺功能有显著的保护作用。Objective ：To observe the effect of the Salvia mihiorrhiza water extract on rat pancreatic function in experi- mental diabetes mellitus and make sure its therapeutic effect. Method： By feeding high - glucose - high - fat diet of 90 male Wistar rat and tail vein injection of streptozotocin （25 mg/kg） ,we established diabetes mellitus （DM） model. All the model rats were randomly divided into blank group, model group, western medicine group, Chinese medicine group （ high, middle and low dose groups）. After the treatment for 4 weeks,the marker of pancreatic functions, such as FPG,in- sulin, MDA and SOD were tested of each group. Results ： Compared with the model group,the treatment effect of diabetes mellitus rats in both traditional Chinese medicine group and Western medicine group were significantly. FPG, insulin, MDA and SOD were better than those in the model group （P 〈 O. O1 ）. For Chinese medicine group,with the increase of dose, the effect increased significantly, and the effect of large dose of Chinese medicine group was the best and better than that of other treatment groups （P 〈 0.01 ）. Conclusion：Salvia mihiorrhiza waterextract has significant protective effect on diabetes mellitus rats and it can improve pancreatic function.

关 键 词：糖尿病 白花丹参 胰腺功能 保护作用 

分 类 号：P285.5[天文地球—地图制图学与地理信息工程]