益肾汤治疗早期慢性肾功能衰竭的临床疗效及对相关指标的影响  

Clinical Effect of Yishen Decoction for Chronic Renal Failure and Effect of Related Indices

作　　者：周海明[1] 韩俊俊[1] 毛慧鹃 

机构地区：[1]浙江省人民医院药学部,浙江杭州310014 [2]江苏省人民医院肾内科,江苏南京210029

出　　处：《中华中医药学刊》2014年第9期2259-2261,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：江苏省指导性科研项目(Z201002)

摘　　要：目的:探讨益肾汤治疗早期肾功能衰竭的疗效,观察其对相关指标的影响。方法:选取2011年11月—2013年10月确诊的慢性肾功能衰竭患者82例,随机分为治疗组41例,对照组41例。对照组给予肾衰宁胶囊,治疗组给予益肾汤治疗。两组均在西医常规治疗的基础上进行。6周为1个疗程,两组均治疗12周,观察疗效及相关指标。结果:治疗组显效率为39.02%、有效率为87.80%明显高于对照组显效率17.07%、有效率65.85%,两组比较具有统计学意义(P<0.05)。两组中医症状积分、肾功能指标、Hb、ALB、PAB均较治疗前明显改善(P<0.05),治疗组较对照组改善显著,组间比较具有统计学意义(P<0.05)。结论:益肾汤能够改善慢性肾衰竭患者临床症状及肾功能,改善肾性贫血,延缓慢性肾衰竭进程。Objective： To investigate the clinical effect and related index of Yishen Decoction in chronic renal failure. Methods ： 82 patients were randomly assigned to 2 groups, 41 in treatment group and 41 in control group. Those patients diagnosed with chronic renal failure were treated in Zhejiang Province People＇s Hospital during November 2011 to October 2013. The control group was treated with Shenshuaining capsule and the treatment group was treated with Yishen Decoction. The time for treatment was 12 weeks. By observing the changes of symptom scores, blood urea nitrogen （ BUN）, serum creatinine （Scr）, endogenous creatinine clearance rate（Ccr） , hemoglobin （Hb） and plasma albumin （Alb）, we made the assessment of curative effect. Result： With treatment, the improvement rate and the efficient rate was 39.02%, 87.80% in treatment group. By contrast, the improvement rate and the efficient rate was 17.07%, 65.85% in control group respectively. Results showed significant difference in the improvement rate and the efficient rate of two groups （ P 〈 O. 05 ）. The treatment group was better than the control one in improving the scores of Chinese medicine symptoms, surpassing the control one （ P 〈 0.05 ）. Obviously decreased BUN,Scr and enhanced Ccr of the treatment group were all better than those of the control one （P 〈 O. 05）. The treatment group obviously surpasses the control one in improving Hb, Alb and PAB （P 〈 0. 05）. Conclusion： According to the results, we can draw a conclusion that Yishen Decoction can effectively improve patients ＂clinical symptoms, renal function and renal anemia. This therapy could curb the further deterioration of the CRF.

关 键 词：益肾汤 肾功能衰竭 中医药治疗 健脾益肾 

分 类 号：R285.6[医药卫生—中药学]