流行性乙型脑炎患者机体氧化还原态初探  

Reasearch on the redox status in patients with epidemic encephalitis B

作　　者：陈夙文 韩晓群[1] 

机构地区：[1]湖北省武汉市医疗救治中心,武汉市430023

出　　处：《中华实验和临床感染病杂志（电子版）》2014年第4期50-52,共3页Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)

摘　　要：目的探讨流行性乙型脑炎患者机体氧化还原态。方法选取40例流行性乙型脑炎患儿为研究对象,分别测定发病极期和恢复期血浆还原型谷胱甘肽(GSH)与氧化型谷胱甘肽(GSSG),还原型辅酶Ⅱ(NADPH)与氧化型辅酶Ⅱ(NADP+),计算GSH/GSSG和NADPH/NADP+比值,评价HIV/AIDS患者机体氧化还原态。结果流行性乙型脑炎患儿发病极期血浆氧化还原态向氧化方向偏移。结论氧化还原态失衡、氧化还原态向氧化方向偏移与流行性乙型脑炎疾病进展有一定相关性。Objective To investigate the redox status in patients with epidemic encephalitis B. Methods Plasma glutathione （reduced form GSH and oxidized form GSSG） were measured by fluorescence spectrophotometry, reduced form NADPH and oxidized form NADP^＋ were measured by UV spectrophotometry in very period and recovery time. Redox status was evaluated by GSH/GSSG and NADPH/NADP＋. Results The GSH/GSSG and NADPH/NADP^＋ redox status in plasma of patients deviated to pro-oxidative direction in the critical stage. Conclusions The imbanlance and deviation to prooxidative direction of redox status closely related with the occurrence and development of epidemic encephalitis B.

关 键 词：流行性乙型脑炎 氧化还原态 

分 类 号：R512.32[医药卫生—内科学]