信号转导和转录激活因子-3基因多态性与河南汉族人群肥胖易感性的关系  

Association of STAT3 gene polymorphism with the susceptibility of obesity in Henan Han population

作　　者：李玉倩[1] 王重建[2] 郭奕瑞[2] 赵秋民[2] 李琳琳[2] 刘晓田[2] 张路宁[2] 别荣海[2] 

机构地区：[1]郑州大学药学院临床药理学教研室,郑州450001 [2]郑州大学公共卫生学院流行病学教研室,郑州450001

出　　处：《郑州大学学报（医学版）》2014年第4期480-483,共4页Journal of Zhengzhou University(Medical Sciences)

基　　金：国家自然科学基金资助项目U1204823;U1304821;河南省医学科技攻关计划基金资助项目201204051

摘　　要：目的：探讨信号转导和转录激活因子-3（STAT3）基因rs2293152位点多态性与河南汉族人群肥胖易感性的关系。方法：采用整群抽样的方法收集河南省某农村地区汉族肥胖病例379人（病例组）和体重正常对照391人（对照组）,应用限制性酶切片段长度多态性分析STAT3基因多态性;采用logistic回归模型分析基因多态性与肥胖的关联强度;采用MDR模型分析基因-环境之间的交互作用。结果：病例组和对照组STAT3基因rs2293152位点（CG＋CC）和GG基因型频率分布差异有统计学意义（χ2=4.712,P=0.029）。调整年龄、性别等因素后,rs2293152位点（CG＋CC）基因型携带者肥胖危险性升高（调整OR=1.391;95%CI：1.009~1.919）。基因-环境交互作用分析显示STAT3基因rs2293152位点和吸烟存在基因-环境交互作用（P〈0.05）。结论：STAT3基因rs2293152位点多态性与肥胖有关联,且该基因多态性和吸烟对肥胖的发生具有交互作用。Aim： To explore the association of rs2293152 polymorphism of single transducer and activator of transcription-3（ STAT3） gene with the susceptibility of obesity in Henan Han population. Methods： The single nucleotide polymorphisms of STAT3 gene rs2293152 in 379 obese and 391 controls were detected by restriction fragment length polymorphism.The relation between STAT3 polymorphism and obesity was estimated by logistic regression model. Gene-environment interaction was evaluated by non-parametric multifactor dimensionality reduction（ MDR） model. Results： The genotype（ CG ＋CC） and GG frequency of rs2293152 between case and control group had statistical difference（ χ2= 4. 712,P =0. 029）. Further analysis revealed that genotype（ CG ＋ CC） of STAT3 gene rs2293152 polymorphism increased the risk of obesity after adjusting age,gender etc（ adjusted OR = 1. 391; 95% CI： 1. 009- 1. 919）. Gene-environment interaction analysis presented a best model consisted of two factors（ rs2293152 and smoking）（ P〈0.05）. Conclusion： STAT3 gene rs2293152 polymorphism is associated with the risk of obesity,and there may be significant interaction between rs2293152 polymorphisms and smoking.

关 键 词：肥胖 信号转导和转录激活因子-3 基因多态性 交互作用 

分 类 号：R181.2[医药卫生—流行病学]