血清胱抑素C水平与冠心病病变的关系  

T（o） relationship of serum cystatin C level to the lesion of coronary heart disease

作　　者：王忠祥[1] 金伟东[2] 宗刚军[3] 

机构地区：[1]解放军101医院急诊科,江苏省无锡市214044 [2]南通大学第三附属医院心内科 [3]解放军101医院心内科,江苏省无锡市214044

出　　处：《中国心血管病研究》2014年第9期808-811,共4页Chinese Journal of Cardiovascular Research

摘　　要：目的 评估血清胱抑素C（Cys C）水平与冠心病病变稳定性、病变严重程度的关系.方法 经冠状动脉造影入选199例患者,其中冠心病组128例,对照组71例;冠心病组再根据病变血管支数、临床类型分为各亚组.比较各组患者临床和生化指标是否有统计学意义.结果 冠心病组血清CysC水平显著高于对照组（P＜0.01）,不稳定型心绞痛组显著高于稳定型心绞痛组和对照组（P＜0.01）,AMI组明显低于SAP组及UA组（P＜0.01）,与对照组比较差异无统计学意义（P＞0.05）.血清Cys C水平与Gensini评分呈正相关（r=0.417,P＜0.01）.结论 血清Cys C水平与冠脉病变的稳定性相关,在一定程度上可以反映其病变的严重程度.Objective To evaluate whether serum Cys C level correlates with stability and severity of coronary atherosclerosis.Methods 199 patients with suspected CHD underwent coronary angiography （CAG） were retrospectively analyzed and divided into 2 groups according to the result：CHD group （128 cases） and non-CHD group （71 cases）.The CHD patients were further divided into different subgroups according to the number of diseased coronary branches and the clinical types.Results The Cys-C level in CHD group was higher than that in non-CHD group （P〈0.01）.As the number of diseased coronary artery increasing,Cys C and Gensini score rose obviously （P〈0.05）.The Cys-C level in UA group was higher than SAP and non-CHD group （P〈0.01）,SAP group was higher than non-CHD group （P〈0.01）,but AMI group was lower than SAP and UA group （P〈0.01）.The Cys-C level in AMI group and that in non-CHD group have no statistically significant difference （P〉0.05）.Cys C has a positive correlation with Gensini score （r=0.417,P〈0.01）.Conclusion Serum Cys C levels are closely associated with the stability of coronary artery disease.Serum Cys C levels is a strong predictor for the severity of coronary artery disease.

关 键 词：冠状动脉疾病 胱抑素C GENSINI评分 冠状动脉造影 

分 类 号：R541.4[医药卫生—心血管疾病]