急性心肌梗死患者HLA-DRB1基因与抗心肌肌球蛋白重链抗体相关性的研究  

Association between HLA-DRB1 gene polymorphism and presence of anticardiac myosin heavy chain antibodies in patients with acute myocardial infarction

作　　者：徐秋梅[1] 龚非力[2] 王秋芬[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院综合科,武汉430022 [2]华中科技大学同济医学院免疫学系,武汉430030

出　　处：《中国免疫学杂志》2014年第9期1233-1235,共3页Chinese Journal of Immunology

基　　金：湖北省自然基金(2012FFB02604)

摘　　要：目的:探讨急性心肌梗死后产生抗心肌肌球蛋白抗体的遗传易感性。方法:借助PCR/序列特异性引物(SSP)技术分析46例急性心肌梗死患者的HLA-DRB1等位基因型别,并检测其抗心肌肌球蛋白重链抗体(AMHCA)。结果:AMHCA阳性组HLA-DRB1*15基因频率较抗体阴性组明显增高(61.53%对18.18%,P<0.05),RR=7.2。其他等位基因频率在两组间差异无显著性。结论:HLA-DRB1*15基因可能与部分急性心肌梗死患者AMHCA的产生有关。Objective：To evaluate the hereditary susceptibility of the production of anti-cardiac myosin heavy chain antibodies （AMHCA） in response to acute myocardial infarction. Methods： 46 patients with acute myocardial infarction were characterized for AMHCA in ELISA and typed the alleles of HLA-DRB1 by PCR/SSP. Results： Significant elevation of the frequency of HLA-DRB1 ＊ 15 allde was detected in AMHCA positive group when compared against AMHCA negative group （61.53% vs 18. 18% ,P〈0. 05） ,RR=7.2, while the frequency of other HLA-DRB1 alleles showed no obvious difference between the two groups. Conclusion： HLA-DRB1 ＊ 15 allele may be involved in the production of AMHCA following acute myocardial infarction in some patients.

关 键 词：抗体 肌球蛋白 心肌梗死 人类白细胞抗原 

分 类 号：R541.4[医药卫生—心血管疾病]