夫西地酸钠乳膏的处方筛选及稳定性考察  

Study on stability and prescription screening of sodium fusidate cream

作　　者：杨丽珍[1] 杨柳[2] 余邦良[2] 

机构地区：[1]海南省人民医院药学部,海南海口571102 [2]海南医学院药学院,海南海口571119

出　　处：《海南医学》2014年第17期2555-2557,共3页Hainan Medical Journal

摘　　要：目的筛选夫西地酸钠乳膏的最佳处方。方法采用L9(34)正交试验优选处方,以白凡士林用量(A)、液状石蜡用量(B)、羊毛脂用量(C)、十六醇用量(D)为考察因素,以外观性状、离心结果、耐寒、耐热四状态总评分和含量为质量评价指标。结果按评价指标确定最优处方组合为A1B3C1D3,用此处方制备3批夫西地酸钠乳膏样品,符合其质量标准和《中国药典》(2010年版)乳膏剂项下的各项规定,其稳定性考察的各项指标均符合要求。结论该处方设计方案合理,结果可靠。Objective To screen the best prescription of sodium fusidate cream. Methods The optimal prescription combination was determined by orthogonal experimental design L9（34） with the dosage of white Vaseline product （A）, Liquid Paraffin （B）, t lanolin （C） and hexadecanol （D） as consideration factors. The appearance and characteristics, centrifugation result, cold-resistant and thermotolreance were taken as quality evaluation indexes. Results The optimal prescription combination was A1B3C3D3. Three batchs of sodium fusidate cream were prepared with A1B3C3D3 prescription. The indexes were all corresponded with the quality standard and examination of Ch.P 2010, and the stability was good. Conclusion The prescription is reasonable and the result is reliable.

关 键 词：夫西地酸钠 乳膏剂 正交试验 稳定性 

分 类 号：R978.1[医药卫生—药品]