改善睡眠质量对伴睡眠障碍的2型糖尿病患者的影响  

Impact of improved quality of sleep on type 2 diabetes patients with sleep disorders

作　　者：刘洪丽[1] 韩颖[1] 吴英凤[1] 郭红磊[2] 

机构地区：[1]天津市大港油田总医院内科,天津300280 [2]天津医科大学代谢病医院糖尿病科卫生部激素与发育重点实验室,天津300070

出　　处：《海南医学》2014年第18期2667-2669,共3页Hainan Medical Journal

基　　金：国家自然科学基金资助项目(编号:8117077);天津市自然科学基金资助项目(编号:12JCYBJC17700)

摘　　要：目的探讨改善睡眠质量对伴有睡眠障碍的2型糖尿病患者的影响。方法通过匹兹堡睡眠质量指数问卷筛选伴有睡眠障碍的2型糖尿病患者,66例纳入研究。将研究对象随机分为干预组和对照组。干预组接受睡眠教育及安眠药物治疗3个月后,与对照组进行代谢情况及生活质量的比较。结果研究结束后,干预组的空腹血糖下降1.50 mmol/L,糖化血红蛋白下降0.65%,空腹胰岛素降低3.2 mU/L,收缩压下降10 mmHg,胰岛素抵抗减轻、睡眠质量及生活质量得到改善,差异有统计学意义(P<0.05)。干预组内,62.5%的患者的睡眠质量得到显效或有效改善,其空腹血糖、糖化血红蛋白、空腹胰岛素、胰岛素抵抗等代谢指标的改善更加明显。结论合并睡眠障碍的2型糖尿病患者经过积极改善睡眠质量,有助于改善患者的血糖水平、胰岛素抵抗、提高生活质量。Objective To evaluate the impact of improved quality of sleep on metabolism indicators and quality of life in patients with type 2 diabetes associated with sleep disorders. Methods Patients with type 2 diabetes associated with sleep disorders were screened through the Pittsburgh Sleep Quality Index questionnaire. At last, 62 cas-es participated in the study. The subjects were randomly divided into intervention group and control group. Interven-tion group received treatment with sleep education and insomnia drugs for 3 months, and then compared with control group in metabolic indicators and quality of life. Results At the end point, metabolism indicators and quality of life in intervention group had improved, including that fasting blood glucose decreased 1.50 mmol/L, glycosylated hemo-globin dropped 0.65%, fasting level of insulin reducing 3.2 mU/L, systolic blood pressure declined 10 mmHg, the insu-lin resistance lowered, quality of sleep and quality of life were improved, these differences were statistically signifi-cant （P〈0.05）. 62.5%patients in intervention group had improved quality of sleep with significant effective or effec-tive. Their metabolic indicators, such as fasting blood glucose, glycosylated hemoglobin, fasting level of insulin, insu-lin resistance, were improved significantly compared with the whole intervention group. Conclusion The merger of sleep disorders in patients with type 2 diabetes needs active treatment so as to improve the patient＆#39;s blood glucose lev-els, insulin resistance, and the quality of life.

关 键 词：睡眠障碍 2型糖尿病 胰岛素抵抗 生活质量 

分 类 号：R587.1[医药卫生—内分泌]