芪甲利肺胶囊辅助治疗复治涂阳肺结核近期疗效观察  

作　　者：席秀娥[1] 李明瑛[1] 王霞[1] 

机构地区：[1]新乡医学院第一附属医院结核内科,河南卫辉453100

出　　处：《中国医师进修杂志》2014年第25期46-49,共4页Chinese Journal of Postgraduates of Medicine

摘　　要：目的探讨芪甲利肺胶囊辅助治疗复治涂阳肺结核的疗效及安全性。方法将160例复治涂阳肺结核患者按人院先后顺序随机分为观察组和对照组，每组80例，所有患者均采用3SHRZE／6HRE方案抗结核治疗，观察组在此基础上加用芪甲利肺胶囊。比较两组痰菌阴转率、病灶显效率、空洞闭合率、细胞免疫功能及临床症状改善等方面的差异。结果观察组和对照组分别有77例和78例患者完成试验；强化期结束时和疗程结束时观察组的痰菌阴转率[79．2％（61／77），92．2％（71／77）]高于对照组[64．1％（50，78），78．2％（61／78）]，差异有统计学意义（P〈0．05）；强化期结束时观察组的病灶有效率及空洞闭合率分别为74．0％（57，77），26．O％（20，77），均高于对照组的52．6％（41／78）和11．5％（9／78），差异有统计学意义（P〈0．05）；疗程结束时观察组的病灶有效率及空洞闭合率分别为92．2％（71/77），54．5％（42／77），均高于对照组的76．9％（60／78）和29．5％（23／78），差异有统计学意义（P〈0．05）；治疗结束后观察组CD3^＋,CD4^＋、CD4^＋／CD8^＋明显高于对照组，差异有统计学意义（P〈0．05）；观察组发热、咳嗽、咳痰、胸闷、胸痛症状缓解时间明显短于对照组，差异有统计学意义（P〈0．05）。口服芪甲利肺胶囊的不良反应发生率为1．3％（1，77）。结论芪甲利肺胶囊辅助治疗复治涂阳肺结核能提高患者的细胞免疫功能，提高痰菌阴转率、病灶显效率及空洞闭合率，加快临床症状的缓解，临床用药较安全。Objective To evaluate the efficacy and safety of Qijialifei capsule,a kind of Chinese traditional medicine,as adjuvant chemotherapy for retreatment patients with smear positive pulmonary tuberculosis.Methods One hundred and sixty retreatment cases with smear positive pulmonary tuberculosis were divided into observation group (80 cases) and control group (80 cases).All patients received the therapy of 3SHRZE/6HRE.The patients in observation group took Qijialifei capsule.Then comparisons were made between two groups in the sputum tubercle bacillus conversion rate,focus improvement rate,cavity closing rate,the cellular immune function,and clinical symptom improvement.Results In 160 cases,77 cases in observation group and 78 cases in control group completed the treatment.At the end of intensified therapy period and at the end of the whole therapy the sputum tubercle bacillus conversion rate [79.2％ (61/77),92.2％ (71/77)] in observation group were significantly higher than those in control group [64.1％ (50/78),78.2％ (61/78)](P ＜ 0.05).The focus improvement rate,cavity closing rate in observation group [74.0％(57/77),26.0％(20/77)] were significantly higher than those in control group [52.6％ (41/78),11.5％ (9/78)] (P ＜ 0.05).At the end of intensified therapy period,the focus improvement rate,cavity closing rate in observation group [92.2％ (71/77),54.5％ (42/77)] were significandy higher than those in control group [76.9％ (60/78),29.5％ (23/78)] (P ＜ 0.05).By the end of the whole therapy,the number of CD3+,CD4+,CD4+/CD8+ of patients in observation group were significantly higher than those in control group (P ＜ 0.05).The disappearance of clinical symptoms in observation group was shorter than that in control group(P ＜ 0.05).The rate of side effects on Qijialifei capsule was only 1.3％(1/77).Conclusions Qijialifei capsule can improve the cellular immune function of the patients,can effectively alleviate the symptoms and can improve the sputum tubercle bacillus conversion rate,radiographic foc

关 键 词：结核 肺 复治 中药疗法 抗结核药 

分 类 号：R521[医药卫生—内科学]