重症急性心肌炎伴心力衰竭患者应用重组人脑利钠肽治疗的临床研究  

Clinical research of restructuring human brain natriuretic peptide treatment of in heart failure associated with severe acute myocarditis

作　　者：王洪云[1] 程艳[2] 秦亮[1] 

机构地区：[1]山东省滨州市人民医院心内科,256610 [2]山东省滨州市人民医院神经内科,256610

出　　处：《中国医师进修杂志》2014年第25期58-60,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的探讨重组人脑利钠肽治疗重症急性心肌炎伴心力衰竭的临床效果。方法将50例重症急性心肌炎伴心力衰竭患者按照随机数字表法分为试验组和对照组，每组25例，对照组给予常规治疗，试验组在对照组治疗的基础上，给予重组人脑利钠肽。两组用药前后检测N-末端脑钠肽前体、左心室射血分数、尿量、肌酐，观察用药前后临床症状（呼吸困难、胸痛、水肿、颈静脉充盈）的改善情况。结果两组用药前N-末端脑钠肽前体、左心室射血分数、尿量、肌酐比较差异无统计学意义（P〉0．05），试验组用药后各临床指标均优于对照组[（7785±432）ng／L比（10022±447）ng／L、（45．28±2．67）％比（41．34±3．11）％、（1833±49）ml／24h比（1456±47）ml／24h、（109．34±10．77）μmol／L比（125．44±11．00）μmol／L]，差异有统计学意义（P〈0．05）。试验组用药后临床症状改善率明显高于对照组[71．4％（55／77）比26．0％（20／77）]，差异有统计学意义（P〈0．01）。结论重组人脑利钠肽联合常规治疗可以有效改善重症急性心肌炎伴心力衰竭患者的临床症状，提高临床的治疗效果。Objective To explore the clinical effect of restructuring human brain natriuretic peptide in treatment of heart failure associated with severe acute myocarditis. Methods Fifty cases of heart failure associated with severe acute myocarditis were divided into experimental group and control group according random number table method, each group 25 cases. The patients in control group were given conventional treatment, and the patients in experimental group were given restructuring human brain natriuretic peptide on the basis of conventional treatment. The clinical effects of two groups were observed. Results The level of N terminal brain natriuretic peptide, left ventricular ejection fraction, urine volume, creatinine in two groups had no significant difference before treatment （P 〉 0.05 ）. After treatment, these index in experimental group were better than those in control group [ （7 785 ±432） ng/L vs. （10 022 ±447） ng/L, （45.28± 2.67）% vs. （41.34 ±3.11）%, （1 833±49） ml/24 h vs. （1 456±47） ml/24 h, （109.34 ± 10.77） μmol/L vs. （ 125.44 ± 11.00） μmol/L ] （P 〈 0.05 ）. The rate of clinical symptoms improving in experimental group was significantly higher than that in control group [71.4% （55/77） vs. 26.0% （20/77）] （P 〈0.01）. Conclusion Restructuring human brain natriuretie peptide with conventional treatment can effectively improve heart failure associated with severe clinical symptoms of acute myocarditis, improve the clinical therapeutic effect.

关 键 词：心力衰竭 重症急性心肌炎 重组人脑利钠肽 

分 类 号：R541.6[医药卫生—心血管疾病]