慢性肾功能不全患者使用头孢哌酮钠他唑巴坦钠致抽搐6例报道  

Six cases of convulsions caused by cefoperazone sodium and tazobactam sodium in chronic renal failure patients

作　　者：张圣雨[1] 邢海燕[2] 姜玲[1] 史天陆[1] 

机构地区：[1]安徽医科大学附属省立医院药剂科,安徽合肥230001 [2]安徽省合肥市第二人民医院药剂科,安徽合肥230011

出　　处：《安徽医药》2014年第11期2193-2195,共3页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探讨肾功能不全患者在使用头孢哌酮钠他唑巴坦钠时可能会引起抽搐,引起有关医务人员关注。方法通过临床药师收集肾功能不全患者在正常用法用量下使用头孢哌酮钠他唑巴坦钠时引起抽搐的6例案例,分析其可能原因。结果 6例慢性肾功能不全患者,因感染给予头孢哌酮钠他唑巴坦钠静脉滴注。连续用药后数天,患者突发抽搐,停用头孢哌酮钠他唑巴坦钠后,对症处理后上述症状消失。结论肾功能不全患者使用头孢哌酮钠他唑巴坦钠时须根据内生肌酐清除率调整给药剂量,同时药物的疗程不宜过长,高龄患者更应谨慎,密切关注临床症状,警惕该药不良反应的发生。Objective To discuss the symptoms that chronic renal failure patients given cefoperazone sodium and tazobactam sodium may cause convulsions,which will be considered by medical staff. Methods Clinical pharmacists analyzed possible causes through col-lecting data of six chronic renal failure patients with convulsions which had used cefoperazone sodium and tazobactam sodium in normal usage and dosage. Results The patients were given cefoperazone sodium and tazobactam sodium injection by intravenous drip due to infection. A few days later,patients had sudden convulsions owing to continuous application,and the symptoms of patients disappeared through drug discontinuation and suitable treatment. Conclusions Cefoperazone sodium and tazobactam sodium injection in chronic re-nal failure patients should be used carefully. The clinical doctors and pharmacists should adjust dosage strictly according to endogenous creatinine clearance rate. Meanwhile drug treatment should not be too long. Drug used in elderly patients should be more cautious. Moni-toring clinical symptoms is essential and at the same time its adverse drug reactions should be alerted.

关 键 词：慢性肾功能不全 头孢哌酮钠他唑巴坦钠 抽搐 

分 类 号：R978.1[医药卫生—药品]