免疫抑制剂对百草枯中毒预后的meta分析  

The prognosis of Inlmunosuppressive therapy for paraquat poisoning: a Meta-anaiysis

作　　者：黄超发 隋明亮 黎宁君[1] 

机构地区：[1]上海交通大学医学院苏州九龙医院重症医学科,江苏苏州215028

出　　处：《吉林医学》2014年第25期5598-5600,共3页Jilin Medical Journal

摘　　要：目的：探讨免疫抑制剂对百草枯的治疗效果。方法：检索国内外公开发表免疫抑制剂治疗百草枯中毒的中英文文献,通过Stata软件进行Meta分析。结果：根据纳人和剔除标准筛选出10篇文献,其中8篇为历史对照的观察性研究,2篇为随机对照试验研究。Meta分析表明免疫抑制剂对百草枯中毒的预后有显著改善。历史对照的观察性研究RR=0.54,95%CI：0.44~0.66,RCT研究RR=0.76,95%CI：0.62~0.94。结论：免疫抑制剂治疗对百草枯中毒的生存率改善明显。但目前的文献存在异质性,证据尚不够充分。需要进行更多的RCT试验以进一步明确。Objective To evaluate the effect of immunosuppressive therapy for paraquat poisoning. Method Relevant published articles concemed with immunosuppressive therapy for paraquat poisoning both in Chinese and in English were searched,and Meta-analysis was carried out with Stata software. Results Eight non-randomized comparative studies and two randomized controlled trials were enrolled for Meta-analysis according to the inclusion and exclusion criteria. The results indicated the relative risk of immunosuppressive therapy in im-proving mortality of paraquat poisoning were 0. 54（95% CI=0. 44~0. 66）and 0. 76（95% CI=0. 62~0. 94）for non-randomised stud-ies and randomized controlled studies,respectively. Conclusion This anaIysis Suggests that immunosuppressive therapy reduce mortality in paraquat poisoning compared with conventional medical therapy. However,due to significant heterogeneity,a large randomized controlled trial is required to affirm the role of immunosuppression in paraquat poisoning.

关 键 词：百草枯中毒 免疫抑制剂 META分析 预后 

分 类 号：R595.4[医药卫生—内科学]