176例ALT或AST异常的HIV/AIDS病人中医药干预分析  

An intervention study of traditional Chinese medicine (TCM) for abnormal ALT or AST in 176HIV/AIDS patients

作　　者：杨玉琪[1] 方路[1] 刘彦丽[1] 贺铮铮[1] 孙俊[1] 宋娜丽[1] 蔡怡[1] 马克坚[1] 

机构地区：[1]云南省中医中药研究院,昆明650223

出　　处：《中国艾滋病性病》2014年第8期556-558,共3页Chinese Journal of Aids & STD

摘　　要：目的分析肝功能转氨酶异常的艾滋病病毒(HIV)感染者/艾滋病(AIDS)病人(简称HIV/AIDS病人),经中医药连续治疗2年后其临床特征变化。方法收集国家中医药治疗艾滋病试点项目(云南)临床信息数据库中,176例肝功能转氨酶异常的HIV/AIDS病人,对其在中医药干预治疗前后5个时间点(0、6、12、18、24个月),丙氨酸氨基转移酶(ALT)和天门冬氨酸氨基转移酶(AST)进行观察分析。结果病人在中医药干预后6个月、12个月、18个月、24个月,ALT异常患者的比例从100%降低至43.8%、53.5%、42.1%和46.1%,AST异常患者的比例从100%降低至55.2%、51.1%、43.0%和50.4%,差异有统计学意义(P<0.01);ALT大于正常值上限2倍及其以上异常的构成比,从治疗前的28.3%降低至治疗后的17.9%、17.1%(第6、24个月)。结论中医药治疗艾滋病可一定程度降低HIV/AIDS病人的肝功能转氨酶异常,尤其对ALT的作用较为明显。Objective To analyze the clinical characteristics of abnormal hepatic transaminase in patients with HIV/AIDS treated by traditional Chinese medicine （TCM） for two years. Methods Data were collected from 176 HIV/AIDS patients with abnormal hepatic transaminases in the clinical information database of TCM Treatment of AIDS Pilot Project （Yunnan）. ALT and AST at the five points of TCM intervention （0, 6, 12, 18 and 24 months） were analyzed. Results At 6 months, 12 months, 18 months and 24 months of TCM intervention, ALT abnormal rate dropped to 43.8%, 53.5%, 42. 1% and 46.1% from 100%, and AST abnormal rate reduced to 55.2%, 51.1%, 43.0%, and 50.4% from 100%, respectively, suggesting a significant difference （p 〈0.01）. The proportion of ALT greater than 2 times the upper limit of normal decreased from 28.3% at baseline to 17.9% and 17.1% at 6 and 24 months after treatment. Conclusion TCM may to some extent reduce the abnormality of hepatic trans- aminases in HIV/AIDS patients, especially for ATL.

关 键 词：艾滋病 肝功能异常 转氨酶 中医药 

分 类 号：R373.9[医药卫生—病原生物学] R28[医药卫生—基础医学]