右归丸对肾阳虚大鼠垂体-性腺轴动态影响的实验研究  

The dynamic effects of yougui bolus on pituitary-goand axis in the kidney yang dificiency rats

作　　者：马娜[1] 罗来成[1] 王永霞 

机构地区：[1]广东药学院基础学院,广州510006 [2]广东省计划生育专科医院 生殖免疫内分泌研究中心,广州510600

出　　处：《中国医学前沿杂志（电子版）》2014年第8期26-28,共3页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

基　　金：国家自然科学基金项目(30360121;30973977)

摘　　要：目的研究右归丸对肾阳虚大鼠垂体-性腺轴的动态影响。方法选取SD雄性大鼠90只,随机分为正常对照组,模型组和右归丸组。大鼠后肢肌内注射氢化可的松,连续29天,制造肾阳虚证模型。正常对照组、模型组和右归丸组SD雄性大鼠于第8天分别用生理盐水和右归丸煎液灌胃,连续22天。分别于第15、23、30天后采用血清放射免疫法测定SD大鼠血清中垂体-性腺轴激素促卵泡激素(FSH)、黄体生成素(LH)、睾酮(T)的含量,并取垂体和睾丸称取重量。结果右归丸对肾阳虚大鼠垂体-性腺轴的动态变化有明显的调整作用。在实验早期(第15天),FSH与LH、T波动幅度不一致。结论右归丸对肾阳虚大鼠垂体-性腺轴的调整呈动态变化。Objective To explore the change law of kidney yang deficiency syndrome, the dynamic effects of yougui bolus on pituitary-gonad axis in the kidney yang dificiency rats was observed. Method 90 SD male rats were randomly divided into 3 groups, normal control group, model group and yougui bolus group. The rats were given hydrocortisonc by intramuscular injection for 29 days to made dificiency of kidney yang models. Rats in normal control group and model group were administered with normal saline by oral gavage, and rats in yougui bolus group were given by yougui bolus from the 8th day for 22 days. Hormone contents of FSH （follicle stimulating hormone）, LH （luteinizing hormone） and T （testosterone） in sera of the pituitary-target gland axises were measured by radioimmunoassay on the 15th day, 23th day and 30th day. Pituitary and testis were weighed. Result There was an obvious adjustment function ofyougui bolus on pituitary-goand axis in rats with kidney yang deficiency. In the early period, on the 15th day, FSH changed synchronously compared to LH and T. Conclusion The adjustments is dynamic of yougui bolus on pituitary-gonad axis in rats with kidney yang deficiency.

关 键 词：右归丸 肾阳虚 垂体-性腺轴 动态 

分 类 号：R285.5[医药卫生—中药学]