益生菌联合早期肠内营养治疗对重型颅脑损伤患者感染的临床研究  

Effect of probiotics combined with early enteral nutrition in treatment of severe traumatic brain injury patients with infections

作　　者：葛红娟[1] 王奇[2] 郭英[1] 王月娟[1] 何纯川 郭慧君[1] 朱宣辑 

机构地区：[1]吉林大学公共卫生学院,吉林长春130021 [2]吉林医药学院附属医院信息科,吉林吉林132013

出　　处：《中华医院感染学杂志》2014年第17期4324-4326,共3页Chinese Journal of Nosocomiology

基　　金：长春市卫生局规划基金资助项目(CW-2010B-10042)

摘　　要：目的探讨益生菌联合早期肠内营养对重型颅脑损伤患者感染的影响,以期提高临床治疗水平。方法随机选取2010年1月-2013年2月70例重型颅脑损伤感染患者为研究对象,将其随机分为对照组和观察组,各35例,对照组予以早期肠内营养,观察组在对照组基础上加用益生菌治疗,观察两组治疗效果。结果对照组与观察组在治疗后的第1天白细胞计数、淋巴细胞计数、C-反应蛋白(CRP)、肿瘤坏死因子-a(TNF-α)、白介素-6(IL-6)比较,差异无统计学意义;而在治疗后的第4、7、15天两组比较,各项指标差异均有统计学意义(P<0.05);对照组感染率为48.57%、病死率为14.29%,观察组分别为25.71%和5.71%;两组治疗后在GCS评分、SOFA评分、APACHE-Ⅱ评分上比较,差异有统计学意义(P<0.05)。结论益生菌联合早期肠内营养对重型颅脑损伤患者感染影响性低,临床效果满意。OBJECTIVE To explore the effect of probiotics combined with early enteral nutrition in treatment of severe traumatic brain injury patients with infections so as to improve the level of clinical treatment. METHODS A total of 70 severe traumatic brain injury patients with infections, who were treated in the hospital from Jan 2010 to Feb 2013, were enrolled in the study and randomly divided into the control group and the observation group,with 35 cases in each~ the control group was treated with early enteral nutrition, and the observation group was given the additional probiotics on the basis of the early enteral nutrition; the therapeutic effect was observed and compared between the two groups. RESULTS After the treatment for one day, the difference in the white blood cells counts, lymphocytes counts, C-reactive protein （CRP）, tumor necrosis factor- α （TNF-α）, or interleukin-6 （IL- 6） between the control group and the observation group was not significant; however, on the fourth, seventh, an fifteenth day after the treatment, there were significant differences in the indicators （P〈0.05）. The incidence of infections was 48.57 % in the control group, 25.71% in the observation group; the mortality rate was 14.29 % in the control group, 5.71% in the observation group. After the treatment, the difference in the GCS score, SOFA score, or APACHE-If score between the two groups was significant （P〈0.05）. CONCLUSION The probiotics combined with early enteral nutrition can achieve satisfactory effect on treatment of the severe traumatic brain injury patients with infections.

关 键 词：益生菌 早期肠内营养 重型颅脑损伤 感染 影响性 

分 类 号：R181.32[医药卫生—流行病学]