补肾通督胶囊对肾虚寒凝型RA患者OPG/RANKL/RANK系统及骨代谢的影响  

Effect of Bushentongdu Capsuleon on OPG /RANKL /RANK System and Bone Metabolism of Patients with Rheumatoid Arthritis

作　　者：林琳[1] 朱阳春[1] 赵慧[2] 侯丽萍[1] 

机构地区：[1]北京中医药大学,北京100029 [2]湖北中医药大学,湖北武汉430065

出　　处：《湖北中医药大学学报》2014年第4期36-39,共4页Journal of Hubei University of Chinese Medicine

基　　金：山西省科技攻关项目(20120313025-8)

摘　　要：目的观察补肾通督胶囊对肾虚寒凝型类风湿性关节炎患者OPG/RANKL/RANK系统及骨代谢的影响。方法入选类风湿性关节炎患者随机双盲分为治疗组(36例)和对照组(35例),治疗组口服补肾通督胶囊,对照组口服雷公藤多甙片,均服药12周,于治疗前后采用DTX-200型骨密度仪检测受试者非优势侧前臂桡尺骨远端三分之一处BMD及采用酶联免疫吸附法(ELISA)观察血清OPG、RANKL、M-CSF、PINP、BGP、BAP。结果补肾通督胶囊可以使RA患者血清OPG、BGP显著升高(P<0.01),RANKL、M-CSF、PINP、BAP显著降低(P<0.01);与对照组相比,治疗组OPG、RANKL变化水平更为明显(P<0.05)及PINP、BAP、BGP变化水平更加显著(P<0.01)。在BMD方面治疗组与治疗前比较无明显差异(P>0.05),对照组与治疗前相比显著降低(P<0.01),但两组间比较无明显差异(P>0.05)。结论补肾通督胶囊对肾虚寒凝型RA患者OPG/RANKL/RANK系统的调节及骨代谢具有良好的调节作用。Objective To investigate the effect of Bushentongdu capsule on OPG/RANKI./RANK system and bone metabolism of patients with rheumatoid arthritis （RA）. Method RA patients were randomly divided into treatment team （ 36 cases） that was treated with Bushentongdu capsule and control team （35 cases） that was treated with Tripterygium glycosides tablet. Both teams were treated for 12 weeks. The changes of serum OPG,RANKL,M -CSF,PINP,BGP and BAP were observed by ELISA and bone mineral density（BMD） were observed by DTX - 200 DXA in two teams before and after the treatment. Results After treatment, serum OPG, BGP significantly evaluated （ P 〈 0. 01 ）and RANKL,M - CSF, PINP, BAP significantly decreased （P 〈 0.01 ） in treatment team. Compared with control team serum OPG, RANKL changed more significantly（P 〈 0. 05 ）, and PINP, BAP, BGP changed much more significantly（ P 〈 0. 01 ）. There were no statistical differences in BMD between two teams（P 〉 0. 05 ）. Conclusion Bushentongdu capsule can regulate RA patients OPG/RANKL/RANK system and bone metabolism effectively.

关 键 词：类风湿性关节炎 补肾通督胶囊 护骨素/核因子kB受体活化因子配体/核因子kB受体活化因子 骨密度 Ⅰ型胶原氨基端前肽 骨钙素 骨特异性碱性磷酸酶 

分 类 号：R285.6[医药卫生—中药学]