双酚A和心血管疾病相关性的研究进展  

Relationship between bisphenol A and cardiovascular diseases: a review of recent studies

作　　者：方超[1] 黄乾生[1] 董四君[1] 

机构地区：[1]中国科学院城市环境研究所,中国科学院城市环境与健康重点实验室,福建厦门361021

出　　处：《环境与健康杂志》2014年第6期556-560,共5页Journal of Environment and Health

基　　金：国家自然科学基金(21207127;21277137;21107107);中国科学院国际创新团队基金(KZCX2-YW-T08);福建省自然科学基金(2011J05117);中国科学院城市环境研究所城市环境与健康重点实验室基金(KLUEH-S-201303)

摘　　要：心血管疾病严重威胁人类健康。最新研究表明,双酚A(BPA)不仅是一类在人体中广泛分布的环境内分泌干扰物,而且已成为诱发和促进心血管疾病发病的一项新的危险因素。因此,亟需结合流行病学调查和实验室研究,深入地阐明BPA和心血管疾病之间的相关性及潜在的致病机制。该文综述了BPA和心血管疾病相关性的最新研究进展,并列举了几类典型的动物模型,以期为将来开展相关的实验室研究提供科学依据。The latest studies support that BPA is not only the widely distributed endocrine disruptors in the humans, but also becomes a new risk factor for inducing and promoting the cardiovascular diseases. Therefore, it is required to combine the epidemiological and experimental studies to deeply clarify the relationship between cardiovascular diseases and BPA as well as the underlying toxicological mechanisms. This paper summarized the latest studies about the relationship between BPA and cardiovascular diseases. Moreover, some typical animal models used in cardiovascular diseases researches were also listed, looking forward to providing scientific reference for experimental studies of the cardiovascular diseases in the future.

关 键 词：双酚A 心血管疾病 动物模型 毒性机制 

分 类 号：R994.6[医药卫生—毒理学]