红花黄色素氯化钠对心肌梗死患者心功能及血液流变学的干预作用  

The interventional effect of safflower yellow sodium chloride on cardiac function and hemorrheologic in patients with myocardial infarction

作　　者：陈翠[1] 吴琼诗[1] 李海涛[2] 

机构地区：[1]海南省人民医院药学部,海南海口570311 [2]海南省人民医院心血管内科,海南海口570311

出　　处：《中国医院药学杂志》2014年第17期1501-1504,共4页Chinese Journal of Hospital Pharmacy

摘　　要：目的:通过观察红花黄色素氯化钠注射液对心肌梗死(AMI)患者心功能和血液流变学的影响,探讨其临床意义。方法:收集2011年5月-2013年4月某院心血管内科收治的AMI患者124例,按照随机单盲法分为观察组与对照组,各62例。2组患者均合理给予抗凝、抗血小板、调脂、抗炎及稳定斑块等西医基础治疗,观察组在此基础上加用红花黄色素氯化钠注射液100 ml静脉滴注,14 d为一个疗程。结果:与对照组相比,观察组患者治疗后,射血分数、每搏量及舒张早期速度峰值改善的更为明显(t=11.136、3.575、9.261,P<0.05),高切及低切全血比黏度、纤维蛋白原均明显降低(t=3.669、8.056、6.887,P<0.05)。结论:红花黄色素氯化钠注射液能明显改善AMI患者的心功能及血液流变学,不良反应少,值得临床推广。OBJECTIVE To observe the impact of safflower yellow sodium chloride injection on cardiac function and hemorrheologic in patients with acute myocardial infarction （AMI）, and to explore its clinical significance. METHOIXS 124 cases of patients admitted with AMI were divided into observation group and control group, 62 cases in each group, according to randomized single blind method from May 2011 to April 2013 in our hospital. Two groups of patients were reasonable given West-ern basic treatment by anticoagulant, antiplatelet, lipid-lowering, anti-inflammatory and stable plaques. Observation group plus safflower yellow sodium chloride injection intravenous infusion based on Western basic treatment, 14d as a course. RESULTS Compared with the control group, in the observation group after treatment, ejection fraction, stroke volume and peak early diastolic velocity were more pronounced improvement （t = 11. 136,3. 575,9. 261, P〈0. 05）. High cut and low-cut whole blood viscosity and fibrinogen were significantly lower （t = 3. 669,8. 056,6. 887,P〈0. 05）. CONCLUSION Safflower yellow chloride injection can significantly improve cardiac function and hemorheology in patients with AMI, has little adverse reac tions, which is worthy of promotion.

关 键 词：红花黄色素氯化钠 心肌梗死 心功能 血液流变学 

分 类 号：R285[医药卫生—中药学]