95%咪唑烟酸原药对大鼠致畸试验的影响分析  

The Effect of Imazapyr 95% TC on Rats Teratogenicity

作　　者：黄晓宇[1] 顾剑[1] 高明伟[1] 王巨晟 鲍清[1] 杨光[1] 林爽[1] 乔开颜 

机构地区：[1]沈阳化工研究院有限公司安全评价中心,沈阳110021

出　　处：《农药》2014年第9期658-659,共2页Agrochemicals

摘　　要：[目的]用Sprague Dawley(SD)大鼠为试材,测定95%咪唑烟酸原药对动物致畸方面的影响。[方法]通过大鼠的致畸试验,来测定95%咪唑烟酸原药对动物致畸的影响。[结果]大鼠经口灌胃给予95%咪唑烟酸原药200、400、800 mg/kg三个剂量组时,95%咪唑烟酸原药对孕鼠及胎鼠的最大无作用剂量为800 mg/kg。[结论]根椐试验的结果并综合其他有关的试验数据,95%咪唑烟酸原药对孕鼠及胎鼠没有明显毒性作用。[Aims] Sprague dawley （SD） rats were used to determine the effect of imazapyr 95% TC on animal teratogenicity. [Methods] The effect of imazapyr 95% TC on animal teratogenicity was determined by rat teratogenicity test. [Results] Imazapyr 95% TC 200, 400, and 800 mg/kg were given to rats by gavage, and the NOAEL to pregnant rats and their pups is 800 mg/kg. [Conclusions] According to the results and other relevant test data, there were no obvious toxic effects on pregnant rats and their pups for imazapyr 95% TC.

关 键 词：致畸试验 妊娠 畸形 咪唑烟酸 

分 类 号：R114[医药卫生—卫生毒理学] TQ457[医药卫生—公共卫生与预防医学]