微小RNA在糖尿病肾病发病机制及治疗中的研究进展  

Research progress of miRNA in the pathogenesis and the treatment of diabetic nephropathy

作　　者：郑林峰[1] 唐文彬[1] 陈立平[1] 

机构地区：[1]中南大学湘雅医院肾内科,长沙410008

出　　处：《临床与病理杂志》2014年第4期435-439,共5页Journal of Clinical and Pathological Research

基　　金：国家自然科学基金青年基金(81100515)~~

摘　　要：微小RNA(microRNAs,miRNA)可在转录后水平调控基因表达。最新研究表明miRNA与糖尿病肾病肾纤维化、足细胞损伤、系膜增生、微血管病变等密切相关,在糖尿病肾病的发病中可能起着必不可少的作用。深入研究miRNA可能为糖尿病肾病的诊断和治疗带来全新的方法。MicroRNAs （miRNAs） can regulate the expression ofgene in the post transcription. Recently, studies demonstrate that miRNA is closely related to renal fibrosis, podocyte injury, mesangial proliferation, and vascular lesions in diabetic nephropathy. MiRNA may play an essential role in the pathogenesis of diabetic nephropathy. Further study on miRNA may bring new methods for the diagnosis and treatment of diabetic nephropathy.

关 键 词：MICRORNA 糖尿病肾病 发病机制 治疗进展 

分 类 号：R587.2[医药卫生—内分泌]