黄芪甲苷对甲基苯丙胺依赖大鼠脑组织中NO、SOD和MDA的影响  

Influence of astragaloside Ⅳon NO,SOD and MDA in methamphetamine-dependence rat brain

作　　者：隋璐[1] 刘坤[1] 沈薇[1] 赵春莹[1] 李新新[2] 

机构地区：[1]沈阳医学院基础医学院,沈阳110034 [2]沈阳医学院法医司法鉴定所,沈阳110034

出　　处：《中国当代医药》2014年第26期16-18,共3页China Modern Medicine

基　　金：辽宁省科技攻关计划项目(2011225020)

摘　　要：目的探讨黄芪甲苷对甲基苯丙胺慢性染毒大鼠脑组织损伤的干预与保护作用。方法建立甲基苯丙胺(MA)慢性染毒大鼠实验动物模型,灌胃给予不同剂量的黄芪甲苷(10 mg/kg,20 mg/kg),观察各组大鼠脑组织海马区和纹状体区一氧化氮(NO)、丙二醛(MDA)和超氧化物歧化酶(SOD)含量的变化及相互关系。结果 MA慢性染毒组脑组织海马区NO、MDA含量显著升高,SOD活力下降,与对照组比较,差异有统计学意义(P<0.01);黄芪甲苷大剂量组(20 mg/kg)与MA模型组相比,脑组织海马区NO、MDA含量降低,SOD活力升高,差异有统计学意义(P<0.01)。结论黄芪甲苷能够降低MA慢性染毒大鼠脑组织海马区NO、MDA含量,升高SOD活力,并通过抗氧化作用对中枢神经系统的损伤有一定的干预与保护作用。Objective To explore the intervention and protective effects of astragaloside Ⅳ on brain tissue in chronic methamphetamine dependent rat model. Methods The chronic methamphetamine dependent rat model was established by intragastric administration of astragasloside Ⅳ.NO,MDA content and SOD activity in hippocampus were detected in different groups. Results In chronic methamphephetamine group,the expression level of NO and MDA was increased, SOD activity was decreased,compared with the control group,there was statistically significance（P〈0.01）.In astragalosideⅣhigh dose group（20 mg/kg）,the content level of MDA was decreased and SOD activity was increased,there was statis-tically significance,compared with chronic methamphephetamine group（P〈0.01）. Conclusion Astragaloside Ⅳ can re-duce the NO and MDA content in the hippocampus MA chronic infected rats,increases SOD activity.On the central ner-vous system damage,Astragaloside Ⅳ has a certain role in the intervention and protection by antioxidant function,and has protective effect on brain tissue.

关 键 词：甲基苯丙胺 黄芪甲苷 一氧化氮 超氧化物歧化酶 丙二醛 

分 类 号：R965[医药卫生—药理学]