MK-801对海洛因成瘾大鼠学习记忆功能的影响  

Effect of MK-801 on learning and memory function of heroin-addictive rats

作　　者：肖邦[1,2] 潘贵书[1] 

机构地区：[1]遵义医学院生理学教研室,贵州遵义563003 [2]川北医学院生理学教研室,四川南充637000

出　　处：《检验医学与临床》2014年第17期2357-2358,2361,共3页Laboratory Medicine and Clinic

基　　金：贵州省省长基金资助项目(c-349)

摘　　要：目的探讨MK-801对海洛因成瘾大鼠学习记忆功能的影响。方法将30只SD大鼠随机分成海洛因成瘾组、MK801组及对照组。采用Morris水迷宫实验中的定位航行实验以及空间探索实验评价各组大鼠学习记忆能力。结果定位航行实验中,各组大鼠逃避潜伏期和搜索距离均随训练进程延长而逐渐缩短;成瘾组大鼠搜索距离大于MK-801组和对照组(P<0.05)。空间搜索实验中,成瘾组大鼠安全岛所在象限搜索时间及安全岛所在象限游泳距离占总距离的百分比均小于对照组及MK-801组(P<0.05),但对照组与MK-801组比较差异无统计学意义(P>0.05)。结论海洛因成瘾可损伤大鼠学习记忆能力,MK-801可减轻海洛因造成的大鼠学习记忆功能损伤。Objective To study the effect of MK-801 on learning and memory function of heroin-addictive rats .Methods Thirty SD rats were randomly assigned into heroin dependent group ,MK-801 group and control group .The ability of special learning and memory were tested by Morris water maze .Results The escape latency and the searching distance of heroin dependent group were significantly longer than control group and MK-801 group in place navigation test （P〈0 .05） .The explore time and the distance of original platform area in proportion to the total distance of heroin dependent group were less than control group and MK-801 group in spatial probe test （P〈0 .05） . Conclusion Heroin dependence could impair the ability of learning and memory of rats .MK-801 could reduce the im-pairment of learning and memory function in heroin dependent rats .

关 键 词：海洛因成瘾 MK-801 MORRIS水迷宫实验 SD大鼠 

分 类 号：R338.64[医药卫生—人体生理学]