抑郁症患者血清脑源性神经营养因子水平测定及临床意义分析  

Clinical significance of serum brain-derived neurotrophic factor in depression

作　　者：程容[1] 周振祥[1] 吕永良[1] 张荣生[1] 钱志平[1] 

机构地区：[1]江苏省苏州市广济医院,215008

出　　处：《检验医学与临床》2014年第17期2371-2372,共2页Laboratory Medicine and Clinic

基　　金：江苏省苏州市科技局科技发展计划应用基础研究项目(YJS0944)

摘　　要：目的探讨抑郁症患者血清脑源性神经营养因子(BDNF)水平与患者性别、年龄、病程、病情严重程度的关系。方法采用酶联免疫吸附法检测91例抑郁症患者和36例健康者血清BDNF水平,并以汉密顿抑郁量表(HAMD)评定抑郁症患者病情严重程度。结果抑郁症患者、健康者血清BDNF水平分别为(24.38±6.27)、(31.44±10.72)μg/L,前者血清BDNF水平低于后者(P<0.05)。抑郁症患者血清BDNF水平与年龄、性别、病程、病情严重程度无相关性(P>0.05)。结论血清BDNF水平降低可能是抑郁症的状态特征之一。Objective To explore the clinical significance of serum brain-derived neurotrophic factor （BDNF） in patients with depression .Methods Serum BDNF level was detected in 91 patients with depression and 36 healthy subjects by using enzyme linked immunosorbent assay .Clinical characteristics were assessed by using Hamilton Rat-ing Scale for Depression （HAMD） .Results Serum BDNF level in patients with depression was （24 .38 ± 6 .27）μg/L ,lower than the （31 .44 ± 10 .72）μg/L in healthy subjects （P〈0 .05） .In patients with depression ,serum level of BDNF was not correlated with age ,gender ,illness course and depressive severity .Conclusion Decreasing of serum BDNF level might be a state characteristic of depression .

关 键 词：抑郁症 脑源性神经营养因子 血清 

分 类 号：R651.2[医药卫生—外科学]