Association of Bisphenol A Exposure with Circulating Sex Hormone Concentrations in Men and Postmenopausal Women  

作　　者：LI Mian WANG Tian Ge XU Yu ZHANG Jie XU Bai Hui XU Min CHEN Yu Hong LU Jie Li Bi Yu Fang WANG Wei Qing GU Yan Yun NING Guang 

机构地区：[1]Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Ruijin Hospital,Shanghai Jiaotong University Medical School, E-Institute of Shanghai Universities [2]Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Ruijin Hospital, Shanghai Jiaotong University Medical School

出　　处：《Biomedical and Environmental Sciences》2014年第8期633-636,共4页生物医学与环境科学（英文版）

基　　金：supported by the grants from Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health(1994DP131044);National Natural Science Foundation of China(No.81170739,81170719,81270877,81222008,81200563);Shanghai New Excellent Youth Program(XYQ2011009);Shanghai Health Bureau(2011293);Shanghai Committee of Science and Technology(12PJ1407700);EFSD-CDS-Lilly Program for Collaborative Research between China and Europe(2011)

摘　　要：A total of 1 116 middle-aged and elderly men and 1 442 postmenopausal women were recruited in this study. Whether bisphenol A exposure was associated with circulating sex hormone concentrations was studied. Univariate analysis revealed that the urinary bisphenol A concentration was negatively correlated with the serum levels of luteinizing hormone （B=-0.061, P〈0.0001） and follicle-stimulating hormone （B=-0.086, P〈0.0001） in men, and with the serum levels of follicle-stimulating hormone （B=-0.037, P=0.018） and sex hormone-binding globulin （B=-0.043, P=0.006） in women. However, no significant association was observed between the serum levels of urinary bisphenol A and circulating sex hormone after adjustment for the potential confounders.A total of 1 116 middle-aged and elderly men and 1 442 postmenopausal women were recruited in this study. Whether bisphenol A exposure was associated with circulating sex hormone concentrations was studied. Univariate analysis revealed that the urinary bisphenol A concentration was negatively correlated with the serum levels of luteinizing hormone （B=-0.061, P〈0.0001） and follicle-stimulating hormone （B=-0.086, P〈0.0001） in men, and with the serum levels of follicle-stimulating hormone （B=-0.037, P=0.018） and sex hormone-binding globulin （B=-0.043, P=0.006） in women. However, no significant association was observed between the serum levels of urinary bisphenol A and circulating sex hormone after adjustment for the potential confounders.

关 键 词：SHBG Association of Bisphenol A Exposure with Circulating Sex Hormone Concentrations in Men and Postmenopausal Women FSH 

分 类 号：R711.75[医药卫生—妇产科学]