Influence of Soy Isoflavone on Lindane Cumulant in Sprague-Dawley Rats  

作　　者：YANG Yang ZHANG Yun Bo SHENG Wei FU Zheng Hai WANG Zhe WANG Xiao GUAN Si Yuan NA Xiao Lin 

机构地区：[1]Department of Environmental Hygiene, Public Health College, Harbin Medical University [2]Department of Chemistry, Zhejiang University

出　　处：《Biomedical and Environmental Sciences》2014年第8期637-640,共4页生物医学与环境科学（英文版）

基　　金：supported by Natural Science Foundation of China(30972439)

摘　　要：Female Sprague-Dawley rats weighing 60-80 t were given different dosages of soy isoflavone! and/or lindane for four weeks. Soy isoflavones wa! added in feed and lindane was given by oral gavag（ We found that soy isoflavones could reduce the level of lindane in rat＇s serum and brain, but might cause the uterus hyperplasia. Lindane could inhibit the effect of soy isoflavones on uterus and significantly decrease the level of estradiol and testosterone in serum. This study indicated that soy isoflavones could reduce the level of lindane in rat＇s body. Lindane could reduce the level of hormones and decreased the effect of soy isoflavones on rat＇s uterus.Female Sprague-Dawley rats weighing 60-80 t were given different dosages of soy isoflavone! and/or lindane for four weeks. Soy isoflavones wa! added in feed and lindane was given by oral gavag（ We found that soy isoflavones could reduce the level of lindane in rat＇s serum and brain, but might cause the uterus hyperplasia. Lindane could inhibit the effect of soy isoflavones on uterus and significantly decrease the level of estradiol and testosterone in serum. This study indicated that soy isoflavones could reduce the level of lindane in rat＇s body. Lindane could reduce the level of hormones and decreased the effect of soy isoflavones on rat＇s uterus.

分 类 号：R285.5[医药卫生—中药学]