慢性荨麻疹患者血清IL-4、IL-17、IL-23与IFN的表达水平及临床意义  

The expression and clinical significance of serum IL-4,IL-17,IL-23 and IFN-r in patients with chronic urticaria

作　　者：刘丽娟[1] 于英瑶[1] 王琪[1] 马欣[1] 张小鸣[1] 

机构地区：[1]宁夏医科大学总医院皮肤科,宁夏银川750004

出　　处：《宁夏医学杂志》2014年第9期820-821,共2页Ningxia Medical Journal

摘　　要：目的探讨血清细胞因子在慢性荨麻疹患者发病中的临床意义。方法采用酶联免疫吸附试验方法(ELISA),检测50例健康对照组和50例慢性荨麻疹患者血清中IL-4、IL-17、IL-23及IFN的含量,并对资料进行统计分析。结果 50例慢性荨麻疹患者血清中细胞因子IL-4、IL-17、IL-23测定结果均显著高于健康对照组,IFN-r低于健康对照组,差异有统计学意义(P<0.05)。结论与正常组比较,慢性荨麻疹患者外周血中IL-4、IL-17、IL-23分泌水平较高,IFN-γ水平较低,提示这些细胞因子在慢性荨麻疹的发病中发挥了重要的免疫作用。Objective To discuss the role of cytokines in the pathogenesis of chronic urticaria. Methods The serum levels of IL -4, IL - 17, IL -23 and IFN -r in 50 patients with chronic urticaria and 50 healthy in control group were detected using the enzyme linked immunosorbent assay method. The data were analyzed by applying SPSSll. 5 software package. Results Before treatment,the ser- um level of IgE, peripheral blood level of IL -4, IL - 17, IL -23 in 50 patients were significantly higher than those of healthy in control group; the level of IFN - r was lower than that in healthy control group, and there was statistically significant difference （ P 〈 0.05 ）. Conclusion Comparing with control group, the serum IL - 4, IL - 17 and IL - 23 are higher and the IFN - r is lower. It suggests the cy- tokines play an important role of immunological function in the incidence of chronic urticaria.

关 键 词：慢性荨麻疹 细胞因子 

分 类 号：R758.24[医药卫生—皮肤病学与性病学]