冠心病患者血清CyPA水平变化及临床意义  

Serum CyPA level change in patients with coronary heart disease and its clinical significance

作　　者：宣玲[1,2] 吴继雄[1] 唐碧[2] 蔡鑫[2] 

机构地区：[1]安徽医科大学第二附属医院心血管内科,合肥230601 [2]蚌埠医学院第一附属医院心血管内科,安徽蚌埠230004

出　　处：《重庆医学》2014年第25期3278-3280,共3页Chongqing medicine

基　　金：安徽省自然科学基金项目(10040606Q44);蚌埠医学院科研课题(Byky1334)

摘　　要：目的观察冠心病患者血清亲环素A(CyPA)水平变化,探讨其临床意义。方法 64例确诊冠心病的患者(冠心病组),依临床类型分为稳定型心绞痛组(SAP组)、不稳定型心绞痛组(UAP组)、急性心肌梗死组(AMI组);依冠状动脉病变范围分为单支组、双支组、多支组;26例检查正常者为对照组。采用ELISA法测CyPA和基质金属蛋白酶9(MMP-9)水平,免疫散射比浊法测C-反应蛋白(CRP)水平。结果冠心病组CyPA、MMP-9、CRP明显高于对照组(P<0.01);AMI组、UAP组CyPA、MMP-9、CRP明显高于对照组和SAP组(P<0.05),SAP组CyPA、CRP与对照组差异无统计学意义(P>0.05);单支组、双支组、多支组CyPA、MMP-9、CRP显著高于对照组(P<0.05),CyPA、MMP-9、CRP随冠脉病变支数增多而升高(P<0.05)。冠心病组CyPA与MMP-9、CRP呈明显正相关(r=0.772、0.749,P<0.01)。结论冠心病患者CyPA明显升高,CyPA可能与冠心病及斑块稳定性有一定关系。Objective To observe the serum cyclophilin A（CyPA）level change in the patients with coronary heart disease （CHD）and to investigate its clinical significance.Methods 64 patients with CHD（CHD group）were divided into three groups ac-cording to the clinical types：stable angina pectoris（SAP）group,unstable angina pectoris（UAP）group and acute myocardial infarc-tion（AMI）group;which were divided into three groups according to the coronary artery lesion range：single vessel lesion group, double vessels lesions group and multi vessels lesions group;while 26 controls with normal coronary arteries were select as the con-trol group.Serum levels of CyPA and matrix metalloproteinase-9 （MMP-9 ）were detected by ELISA,and C-reactive protein（CRP） concentration was detected by the immune scattering turbidimetry test.Results The CyPA,MMP-9 and CRP levels in the CHD group were significantly higher than those in the control group（P〈0.01）;the CyPA and CRP levels in the AMI group and the UAP group were significantly higher than those in the control group and the SAP group（P〈0.05）,the CyPA and CRP levels had no statistically significant difference between the SAP group and the control group（P〉0.05）;serum CyPA,MMP-9 and CRP levels in the single vessel lesion group,the double vessels lesion group,multi vessels lesion group were significantly higher than those in the control group（P〈0.05）,serum CyPA,MMP-9 and CRP levels were elevated with the increase of coronary artery lesion vessels （P〈0.05）.In the CHD group,serum CyPA with MMP-9 and CRP showed the significantly positive correlation（r=0.772,0.749, P〈0.01）.Conclusion Serum CyPA level is significantly increased in the patients with CHD,CyPA may have some relationship to CHD and the plaque stability.

关 键 词：冠心病 亲环素A 基质金属蛋白酶9 C反应蛋白质 

分 类 号：R541.4[医药卫生—心血管疾病]