晚期鼠脑胶质瘤模型的建立与磁共振灌注成像研究  

Establishment of rat late brain glioma model and magnetic resonance perfusion weighted imaging

作　　者：陈淑玲[1] 郭子义[1] 钟小航[1] 

机构地区：[1]海南省海口市人民医院放射科,570208

出　　处：《重庆医学》2014年第25期3317-3318,3321,共3页Chongqing medicine

摘　　要：目的探讨3.0T磁共振灌注成像技术在晚期鼠脑胶质瘤模型的应用价值。方法 Wistar大鼠32只,通过立体定向仪将C6细胞接种至鼠脑右尾状核区,接种3周后行3.0T常规MRI和磁共振灌注成像检查,记录灌注成像参数局部脑容量(rCBV),并与病理结果进行对照。结果 30只接种大鼠,在随后病理检查中均有肿瘤形成,成瘤率100%;磁共振灌注成像显示胶质瘤瘤体和对侧镜像脑组织的rCBV分别为262.61±72.82和189.39±57.21,两组结果差异有统计学意义(P<0.05)。结论晚期鼠脑胶质瘤模型适合用于脑肿瘤组织血容量的研究。Objective To explore the application value of 3.0T magnetic resonance perfusion weighted imaging（PWI）in the rat late brain glioma model.Methods C6 glioma cells were injected stereotactically into the right caudate nucleus of 32 Wistar rats.In 3 weeks after inoculation,the conventional MRI and PWI were performed.The relative cerebral blood volume（rCBV）values were recorded and compared with the pathological results.Results The tumor formation in 30 inoculated rats were confirmed by the sub-sequent pathological examination,with the tumor formation rate of 100%.PWI showed that rCBV values of the brain glioma region and the contralateral mirror image brain tissue were 262.61±72.82 and 189.39±57.21,the difference between them was statisti-cally significant（P〈0.05）.Conclusion The rat late brain glioma model is suitable for the study on the blood volume of brain tumor tissues.

关 键 词：磁共振成像 大鼠 WISTAR 神经胶质瘤 磁共振灌注成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R739.4[医药卫生—诊断学]