急性冠脉综合征患者氯吡格雷抵抗的研究进展  

Progress of research on clopidogrel resistance in the patients with acute coronary syndrome

作　　者：吕海辰[1] 吴鸿谊[1] 葛均波[1] 

机构地区：[1]复旦大学附属中山医院心内科,上海市心血管病研究所,上海200032

出　　处：《大连医科大学学报》2014年第4期387-392,共6页Journal of Dalian Medical University

摘　　要：氯吡格雷是一种临床常见的抗血小板药物,在急性冠脉综合征患者中应用广泛。长期随访发现,部分患者对氯吡格雷无反应或低反应,即存在药物抵抗现象。氯吡格雷低抗者的血小板聚集率高、不良心血管事件发生率增加。本文对氯吡格雷的作用机制、氯吡格雷抵抗的检测方法、原因及治疗对策等作一综述。Clopidogrel plays a significant role in the prevention of thrombotic events in patients with acute coronary syn -drome,but a substantial number of patients demonstrate no response or low response to the drug ,which is regarded as the phenomenon of drug resistance .Clopidpgrel-resistance patients have higher platelet aggregation and more frequency to suf -fer from adverse cardiovascular events than the others .The mechanism of the reaction and resistance of clopidogrel , meas-urement of clopidogrel resistance together with the treatment strategy are compeahended in this article .

关 键 词：急性冠脉综合征 血小板 氯吡格雷 抵抗 ACUTE CORONARY SYNDROME ( ACS) 

分 类 号：R541.4[医药卫生—心血管疾病]